conclusions combination therapy with tretinoin plus topical corticosteroids is safe and effective and provides an alternative in the treatment of patients with vitiligo. objectives recent studies suggest that administration of topical tretinoin, with a corticosteroid, diminishes skin atrophy without impacting the steroid’s anti-inflammatory effects. patients and methods a placebo-controlled, pa...

results researchers have reported that mirnas can repress the expression of important cancer-related genes and might be helpful in the diagnosis and treatment of cancer. during the past two decades, numerous studies have shown that mirnas play an essential role in inhibiting hcc via several different pathways. deregulated mirnas may contribute to carcinogenesis, indicating that mirnas can act a...

ôbjective: to compare the effectiveness and safety of the methylphenidate produced in ïran (stimdate®) with its original brand (ritalin®) in children with âttention deficit hyperactivity disorder (âdhd). methods: ïn this double-blinded randomized clinical trial, 30 patients with âdhd who were 6 to 16 years old, were divided into two groups: 15 in stimdate® and 15 in ritalin® group. the two grou...

an experiment was conducted on eight weak and anaemic goats revealed pale conjunctivae, increased heart rate, rough hair coat, dullness and depression. the haematology showed significantly decreased haemoglobin (7.37±0.16 g %), packed cell volume (pcv)(23.37±0.56%),total erythrocyte count (tec)(8.12±0.18 million/cumm), mean corpuscular haemoglobin (mch) (9.10±0.30 pg) and mean corpuscular volum...

evidences acquisitions reports over the last decade show that any change in the lifestyle of patient can accelerate the treatment progress. results although islamic fasting is not in available in all religions, the principle of fasting exists in all religions which represents the domination of documented procedures on the human nature. results of the current study showed that islamic fast can b...

background there has been no data on population based dietary patterns during the ramadan fasting month. objectives the purpose of this study was to detect ramadan major dietary patterns among those who fast in tehran. materials and methods this cross-sectional study included 600 subjects, aged 18-65 with body mass index (bmi) of 18.5-40, who had decided to fast during ramadan. anthropometric m...

Insulinoma is a rare, usually benign, pancreatic neuroendocrine tumor. The clinical features of an insulinoma are fasting hypoglycemia with neuroglycopenic symptoms including confusion and unusual behavior, while hypertension is usually not associated with the disease. We herein report a patient with insulinoma who manifested paroxysmal hypertension and neuroglycopenic symptoms. The possible et...

BACKGROUND Glucose intolerance and apolipoprotein ε4 allele (E4+) are risk factors for Alzheimer's disease (AD). Insulin sensitizers show promise for treating AD, but are less effective in E4+ individuals. Little is known about how the APOE genotype influences glucose metabolism. METHODS Cross-sectional analysis of 319 older adults who underwent oral glucose tolerance tests; a subset had insu...

BACKGROUND Prior studies suggest soluble fibers may favorably affect glucose/insulin metabolism. METHODS This prospective, randomized, placebo controlled, double blind, parallel group trial evaluated 50 generally healthy subjects without prior diagnosis of diabetes mellitus (44 completers), who were administered beverages containing placebo (control), lower dose (3 g/d), or higher dose (6 g/d...

Fasting and postprandial hyperglucagonemia in type 2 diabetes mellitus (T2DM) patients cause excessive hepatic glucose production (HGP), suggesting that attenuation of hepatic glucagon action could be a therapeutic strategy for T2DM. In this study we evaluated the safety, tolerability, PK, and pharmacodynamics in healthy human volunteers of single and multiple doses (50-400 mg) ISIS 325568, a 2...