Human genetic studies have emphasised the dominant contribution of pancreatic islet dysfunction to development of Type 2 Diabetes (T2D). However, limited annotation of the islet epigenome has constrained efforts to define the molecular mechanisms mediating the, largely regulatory, signals revealed by Genome-Wide Association Studies (GWAS). We characterised patterns of chromatin accessibility (A...

The complex dynamics of Human Immunodeficiency Virus leads to serious problems on predicting the drug resistance. Several machine learning techniques have been proposed for modelling this classification problem, but most of them are difficult to aggregate and interpret. In fact, in last years the protein modelling of this virus has become, from diverse points of view, an open problem for resear...

We propose a geometric model-free causality measure based on multivariate delay embedding that can efficiently detect linear and nonlinear causal interactions between time series with no prior information. We then exploit the proposed causal interaction measure in real MEG data analysis. The results are used to construct effective connectivity maps of brain activity to decode different categori...

Der Begriff der Topic Map erfährt seit circa zwei Jahren eine moderate, aber deutlich wachsende Beachtung in der Fachöffentlichkeit. Viele Anwendungen zeichnen sich aber durch ihren Demonstrationscharakter aus oder sind akademischer Natur. In diesem Beitrag geht es um ein Pilotprojekt in der Luftfahrtindustrie, das der Verfasser im Rahmen seiner Tätigkeit für die Sörman Information GmbH durchge...

one of the evolutions in tort law is the colectivisation of civil liability. in the past, civil liability was collective and the effects of the person guilty haven imposed on the all members of family. then with developing of civilizations and with appearance of principle of personal liability, the collective liability has been changed to personal liability. but nowadays according to the opinio...

The aim of this study is to investigate Iranian TEFL graduates’ conception of measurement error in research. Adopting a sequential explanatory multi-method strategy (Borg, 2009), the researchers analyzed causal and temporal relations in the research narratives elicited from 30 TEFL graduates. Gee’s (1986) framework for identifying narrative discourse units (lines, stanzas, and episodes) was ado...

Information structure has been assumed to be an autonomous part of grammar for more than 100 years. It is represented as a partition of the sentence into two units, e.g., focus background, topic comment, focus topic, focus presupposition etc.1 Even though information structure is sometimes understood as textual or discourse structure, its organizational level is still defined with respect to th...

Fix a nontrivial interval X C R and let / e C1(X,X) be a chaotic mapping. We denote by Aoo (/) the set of points whose orbits do not converge to a (one-sided) asymptotically stable periodic orbit of / or to a subset of the absorbing boundary of X for /. A. We assume that / satisfies the following conditions: (1) the set of asymptotically stable periodic points for / is compact (an empty set is ...

Collective intelligence, or the wisdom of crowds, refers to a phenomenon by which, under the right conditions, groups of individuals can render highly accurate judgments. This phenomenon has long played an important role in economics, where understanding the behavior of groups is often essential to explaining economic outcomes. More recently, political scientists have shown that trends in publi...

There was a time when the mobilization of experts was a taken-for-prated. unproblematic aspect of decision-making processes. That confidence has vanished. Ascertaining the significance of expertise now requires a reconsideration of the dynamics of controversies. The current view still assimilates conlroversy to the medieval exercise of the disputatio in which two parties argue one against the o...