BACKGROUND In idiopathic pulmonary arterial hypertension (IPAH), peripheral airway obstruction is frequent. This is partially attributed to the mediator dysbalance, particularly an excess of endothelin-1 (ET-1), to increased pulmonary vascular and airway tonus and to local inflammation. Bosentan (ET-1 receptor antagonist) improves pulmonary hemodynamics, exercise limitation, and disease severit...

The timeliness of order deliveries seriously impacts customers’ evaluation logistics services and, hence, has increasingly received attention. Due to the diverse and large quantities orders under background electronic commerce, how pick efficiently while also adapting these features become one most challenging problems for distribution centers. However, previous studies have not accounted diffe...

background: multiple sclerosis (ms) is a neurological disease with a variety of signs and symptoms. exercise therapy has been shown to improve physical functions in ms. however, questions about an optimal exercise therapy remain. in this regard, we suggest a combined exercise therapy including aerobic and resistance exercises for ms patients. the study is designed to observe, test and compare t...

BACKGROUND The Minnesota Living with Heart Failure Questionnaire (MLHFQ) is the most widely used measure of quality of life (QoL) in HF patients. This prospective study aimed to assess the relationship between QoL and exercise capacity in HF patients. METHODS The study subjects were 118 consecutive patients with chronic HF (62 ± 10 years, 57 females, in NYHA I-III). Patients answered a MLHFQ ...

objective(s): a novel iq-specttm method has become widely used in clinical studies. the present study compares the quality of myocardial perfusion images (mpi) acquired using the iq-specttm (iq-mode),conventional (180° apart: c-mode) and l-mode (90° apart: l-mode) systems. we assessed spatial resolution, image reproducibility and quantifiability using various physical phantoms. materials and me...

Abstract Introduction A retrospective analysis was conducted to characterize diagnostic sleep testing during the 12 months before diagnosis of idiopathic hypersomnia (IH), a hypersomnolence disorder with no approved treatments. Methods IBM® MarketScan® claims data were analyzed (1/1/14–9/30/19) identify adults newly diagnosed IH, defined as ≥2 an IH code ≥1 day and ≤180 days apart, without ≤12 ...

When using the statistical inversion framework in microwave tomography (MWT), generally, real and imaginary parts of unknown dielectric constant are treated as uncorrelated independent random variables. Thereby, maximum a posteriori estimates, two recovered variables may show different structur...