Tubulin assembles into microtubule polymers that have distinct plus and minus ends. Most microtubule plus ends in living cells are dynamic; the transitions between growth and shrinkage are regulated by assembly-promoting and destabilizing proteins. In contrast, minus ends are generally not dynamic, suggesting their stabilization by some unknown protein. Here, we have identified Patronin (also k...

The set of the three dimensional polyominoes of minimal area and of volume n contains a polyomino which is the union of a quasicube j × (j + δ) × (j + θ), δ, θ ∈ {0, 1}, a quasisquare l × (l + ), ∈ {0, 1}, and a bar k. This shape is naturally associated to the unique decomposition of n = j(j +δ)(j +θ)+ l(l+ )+k as the sum of a maximal quasicube, a maximal quasisquare and a bar. For n a quasicub...

Analysis of duck hepatitis B viral DNA by gel electrophoresis, Southern blotting, and binding to benzoylated naphthoylated DEAE-cellulose showed that a protein is bound to the minus-strand virion DNA as well as to the full-length single strand, minus-strand species, and minus-strand DNA intermediates isolated from replicating complexes present in infected duck liver. By utilizing a modified did...

The evolutionary conserved NSL complex is a prominent epigenetic regulator controlling expression of thousands of genes. Here we uncover a novel function of the NSL complex members in mitosis. As the cell enters mitosis, KANSL1 and KANSL3 undergo a marked relocalisation from the chromatin to the mitotic spindle. By stabilizing microtubule minus ends in a RanGTP-dependent manner, they are essent...

Oxytocin administered intravenously to the anaesthetized rat produced dilatation of the blood vessels of the cremaster muscle at concentrations ranging from 2.5 times 10-minus 11 to 2.5 times 10-minus 9 M. When applied topically to the exposed vessels it produced constriction at concentrations ranging from 2.5 times 10-minus 12 to 5.0 times 10-minus 8 M. Oxytocin was thus similar to adrenaline ...

A new formula for box-minus operation, which separates the box-minus operation into sign and reliability operations, was derived. Its application in the sum-product algorithm (SPA) was also investigated. Both boxplus operation and box-minus operation were divided into sign operation and reliability operation. The results show that on using the box-minus operation, SPA can be implemented with le...

Microtubules are cytoskeletal filaments that are intrinsically polarized, with two structurally and functionally distinct ends, the plus end and the minus end. Over the last decade, numerous studies have shown that microtubule plus-end dynamics play an important role in many vital cellular processes and are controlled by numerous factors, such as microtubule plus-end-tracking proteins (+TIPs). ...

The authors attempted to replicate prior group brain correlates of deception and improve on the consistency of individual results. Healthy, right-handed adults were instructed to tell the truth or to lie while being imaged in a 3T magnetic resonance imaging (MRI) scanner. Blood oxygen level-dependent functional MRI significance maps were generated for subjects giving a deceptive answer minus a ...

The 3' terminus of the bamboo mosaic potexvirus (BaMV) contains a poly(A) tail, the 5' portion of which participates in the formation of an RNA pseudoknot required for BaMV RNA replication. Recombinant RNA-dependent RNA polymerase (RdRp) of BaMV binds to the pseudoknot poly(A) tail in gel mobility shift assays (C.-Y. Huang, Y.-L. Huang, M. Meng, Y.-H. Hsu, and C.-H. Tsai, J. Virol. 75:2818-2824...