Previous studies have indicated involvement of the thalamus and the pons in Kleine-Levin syndrome. In the present study, functional connectivity of the thalamus and the pons was investigated in asymptomatic patients with Kleine-Levin syndrome and healthy controls. Twelve patients and 14 healthy controls were investigated by functional magnetic resonance imaging during rest. Resting state images...

The thalamus and neocortex are two highly organized and complex brain structures that work in concert with each other. The largest synaptic input to the thalamus arrives from the neocortex via corticothalamic fibers. Using brain slices, we describe long-term potentiation (LTP) in corticothalamic fibers contacting the ventrobasal thalamus. Corticothalamic LTP is input-specific, NMDA receptor-ind...

the present study investigated the effects of microinjections of acetylcholine (a cholinergic agonist), physostigmine (a cholinesterase inhibitor), atropine (an antagonist of muscarinic cholinergic receptors) and hexamethonium (an antagonist of nicotinic cholinergic receptors) into the parafascicular nucleus of thalamus on the acute corneal nociception in rats. acute corneal nociception was ind...

Abstract Background Tourette syndrome (TS) is a neurodevelopmental disorder defined by the continual presence of primary motor and vocal tics. Grey matter abnormalities have been identified in numerous studies TS, but conflicting results reported. This study was an unbiased statistical meta-analysis published neuroimaging TS structures. Methods A voxel quantitative technique called activation l...

Objective Sudden unexpected death in epilepsy (SUDEP) may arise as a result of autonomic dysfunction during seizure. The central networks (CANs) modulate brainstem cardiorespiratory regulation. Recent magnetic resonance imaging (MRI) studies SUDEP have shown cortical and subcortical volume changes altered connectivity between CAN regions, but the pathological correlate is unknown. Because neuro...

The present study investigated the effects of microinjections of acetylcholine (a cholinergic agonist), physostigmine (a cholinesterase inhibitor), atropine (an antagonist of muscarinic cholinergic receptors) and hexamethonium (an antagonist of nicotinic cholinergic receptors) into the parafascicular nucleus of thalamus on the acute corneal nociception in rats. Acute corneal nociception was ind...

The thalamus is a central element for the generation of rhythmic oscillatory activity under physiological and pathophysiological conditions. Especially slow oscillations in the delta and theta frequency band which normally occur during slow-wave sleep are associated with a number of neuropsychiatric conditions if they occur during wakefulness and may be the basis for the generation of character...

The thalamus is a paired structure joined at the midline and located at the center of the brain (Figure 10.1 ). Each half is roughly the size of a walnut. The main part of the thalamus is divided into a number of discrete regions, known as relay nuclei. These contain the relay cells that project to the cerebral cortex. (In this chapter, cortex refers to neocortex, which does not include the hip...

Introduction/Objective. The aim of this study was a detailed examination microanatomy the medial posterior choroidal artery (MPChA). Methods. microanatomical characteristics MPChA were studied in 30 formalin fixed brain hemispheres using 6.3?10 ? magnification stereoscopic microscope. arteries injected with mixture 10% India ink and gelatin. second group 10 consisted specimens methyl methacryla...

Cross-talk between the thalamus and cortex has been implicated in attention but its pathogenic role in attention-deficit/hyperactivity disorder (ADHD) remains unknown. Here, I demonstrate that Git1 (-/-) mice, previously proposed as an animal model for ADHD, show abnormal theta oscillation in the thalamus. Multi-electrode recordings revealed that Git1 (-/-) mice have hyper-synchrony of neural a...