نتایج جستجو برای: tgfβ

تعداد نتایج: 3626  

2016
Qin Bian Amit Jain Xin Xu Khaled Kebaish Janet L. Crane Zhendong Zhang Mei Wan Lei Ma Lee H. Riley Paul D. Sponseller X. Edward Guo Willian Weijia Lu Yongjun Wang Xu Cao

Narrowed intervertebral disc (IVD) space is a characteristic of IVD degeneration. EP sclerosis is associated with IVD, however the pathogenesis of EP hypertrophy is poorly understood. Here, we employed two spine instability mouse models to investigate temporal and spatial EP changes associated with IVD volume, considering them as a functional unit. We found that aberrant mechanical loading lead...

2016
Xi Chen Xinwei Cao Xiaohua Sun Rong Lei Pengfei Chen Yongxu Zhao Yuhang Jiang Jie Yin Ran Chen Deji Ye Qi Wang Zhanjie Liu Sanhong Liu Chunyan Cheng Jie Mao Yingyong Hou Mingliang Wang Ulrich Siebenlist Y Eugene Chin Ying Wang Liu Cao Guohong Hu Xiaoren Zhang

Transforming growth factor beta (TGFβ) signaling in breast cancer is selectively associated with pulmonary metastasis. However, the underlying mechanisms remain unclear. Here we show that Bcl-3, a member of the IκB family, serves as a critical regulator in TGFβ signaling to modulate breast cancer pulmonary metastasis. Bcl-3 expression was significantly associated with metastasis-free survival i...

2016
Jennifer L Uhrlaub Vesna Pulko Victor R DeFilippis Rebecca Broeckel Daniel N Streblow Gary D Coleman Byung S Park John F Lindo Ivan Vickers Joshua J Anzinger Janko Nikolich-Žugich

Chikungunya virus (CHIKV) is a re-emerging global pathogen with pandemic potential, which causes fever, rash and debilitating arthralgia. Older adults over 65 years are particularly susceptible to severe and chronic CHIKV disease (CHIKVD), accounting for >90% of all CHIKV-related deaths. There are currently no approved vaccines or antiviral treatments available to limit chronic CHIKVD. Here we ...

2017
CLAUDIA BELLOMO Lars Holmgren

Bellomo, C. 2018. TGFβ and LXR signaling in hepatocellular carcinoma. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1406. 65 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-513-0175-4. Hepatocellular carcinoma (HCC) is one of the most prevalent cancer types in the Western world and in the Asia-pacific regions, with its incidence expected to rise ...

Journal: :reports of biochemistry and molecular biology 0
mozhgan soltani department of biology, science and research branch, islamic azad university, tehran, iran kazem parivar department of biology, science and research branch, islamic azad university, tehran, iran javad baharara tel: +98 51- 36080498; fax: +98 51- 3608049 mohammad amin kerachian department of medical genetics, faculty of medicine, mashhad university of medical sciences, mashhad, iran javad asili department of pharmacognosy, school of pharmacy, mashhad university of medical sciences, mashhad, iran

background: marine natural products contain a wide range of bioactive compounds with therapeutic properties that have revealed crucial properties in the treatment of some diseases. some of these compounds have recently received considerable attention for drug discovery. in this study we examined the anti-angiogenic effect of saponin isolated from holothuria leucospilota (sea cucumber) through e...

2014
Hasmik Shahinian Daniela Loessner Martin L. Biniossek Jayachandran N. Kizhakkedathu Judith A. Clements Viktor Magdolen Oliver Schilling

Kallikrein-related peptidases, in particular KLK4, 5, 6 and 7 (4-7), often have elevated expression levels in ovarian cancer. In OV-MZ-6 ovarian cancer cells, combined expression of KLK4-7 reduces cell adhesion and increases cell invasion and resistance to paclitaxel. The present work investigates how KLK4-7 shape the secreted proteome ("secretome") and proteolytic profile ("degradome") of ovar...

Journal: :Molecular cancer therapeutics 2014
Ji Yeon Son So-Yeon Park Sol-Ji Kim Seon Joo Lee Sang-A Park Min-Jin Kim Seung Won Kim Dae-Kee Kim Jeong-Seok Nam Yhun Yhong Sheen

Advanced tumors produce an excessive amount of transforming growth factor β (TGFβ), which promotes tumor progression at late stages of malignancy. The purpose of this study was to develop anti-TGFβ therapeutics for cancer. We synthesized a novel small-molecule TGFβ receptor I kinase (activin receptor-like kinase 5) inhibitor termed N-[[4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2...

2012
Yoshimi Sekiguchi Jing Zhang Sarah Patterson Limin Liu Chieko Hamada Yasuhiko Tomino Peter J Margetts

Patients with end-stage kidney disease on peritoneal dialysis often develop progressive scarring of the peritoneal tissues. This manifests as submesothelial thickening and is associated with increased vascularization that leads to ultrafiltration dysfunction. Hypoxia induces a characteristic series of responses including angiogenesis and fibrosis. We investigated the role of hypoxia in peritone...

2013
Hilda Tateossian Susan Morse Andrew Parker Philomena Mburu Nick Warr Abraham Acevedo-Arozena Michael Cheeseman Sara Wells Steve D.M. Brown

Otitis media with effusion (OME) is the most common cause of hearing loss in children and tympanostomy to alleviate the condition remains the commonest surgical intervention in children in the developed world. Chronic and recurrent forms of OM are known to have a very significant genetic component, however, until recently little was known of the underlying genes involved. The identification of ...

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