We report the athletic, physiological and mitochondrial-related genomic data of an Israeli endurance runner. He is holding the Israeli record in 10000, 5000, 1500 and 800m run, along with being one of the best Israeli 400m runners. We tested the ACTN3 R577X, and six polymorphisms in the PPARGC1A-NRF-TFAM pathway genes. The case athlete was heterozygous for the ACTN3 R577X variation and had five...

The Center of Gravity (COG) method is one of the most popular defuzzification techniques of fuzzy mathematics. In earlier works the COG technique was properly adapted to be used as an assessment model (RFAM) and several variations of it (GRFAM, TFAM and TpFAM) were also constructed for the same purpose. In this paper the outcomes of all these models are compared to the corresponding outcomes of...

In this Correspondence, a comment to a recent paper by Nikbakht et al., published in the latest ssu of this Journal is reported. The flavone apigenin can exert both its anti-oxidant potetial via the usual enzymatic ROS scavenging system and the mitochondria biogenesis via the PGC-1α/ TFAM/NRF-1 pathway. The very interesting paper by Nikbakht et al, may earn more insighful clues about the activi...

During experimental hypertensive cardiac hypertrophy, the heart energy metabolism reverts from the normal adult type that obtains the majority of its requirement for adenosine triphosphate (ATP) from metabolism of fatty acids and oxidative phosphorylation (OXPHOS), to the fetal form, which metabolizes glucose and lactate. Mitochondrial synthesis and function require an estimated 1000 polypeptid...

Aged skeletal muscle demonstrates declines in muscle mass and deterioration of mitochondrial content and function. Peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α) plays an important role in promoting muscle mitochondrial biogenesis in response to exercise training, but its role in senescent muscle is not clear. In the present study we hypothesize that a downregulation of t...