Testicular cancer is the most common solid organ tumor in young men and affects men during their reproductive years. Current therapeutic regimens have significantly improved survival but often adversely impact fertility. Understanding the effects of testicular cancer, the systemic effects of neoplasia, and the effects of treatment protocols, such as radiotherapy, chemotherapy, and retroperitone...

The ability of an environmental exposure (i.e. endocrine disruptor) during sex determination to reprogramme the male germline and promote an epigenetic transgenerational disease phenotype suggests that environmental factors and compounds may permanently alter the germline epigenome. This epigenetic transgenerational phenomenon will be discussed with respect to adult-onset germline disease (e.g....

UNLABELLED Undescended testis is a common finding in boys, and the majority of cases have no discernible aetiology. There are unexplained geographical differences and temporal trends in its prevalence. Cryptorchidism, especially bilateral, is associated with impaired spermatogenesis and endocrine function and increases the risk of testicular cancer. There is an urgent need to identify factors t...

background: in cancer patients, chemo and radiotherapy can cause infertility by damaging spermatogenesis process. this process is based on self-renewal and differentiation of a rare population of the testicular cells called spermatogonial stem cells (sscs). scientists have tried to isolate, enrich and culture human spermatogonial stem cells, hoping to resolve infertility problems in cancer reco...

Background: Testicular cancer (TC) is the most common in males between age of 15 and 34 years with an incidence rates for new cases rising on average 0.8% each year over last 10 years. self-examination (TSE) recommended preventive approach to reduce testicular Cancer mortality morbidity.
 Objectives: This study examines knowledge, attitude practice TSE among male undergraduate students.&#x...

OBJECTIVE Striking geographic variation and marked increasing secular trends characterize the incidence of testicular cancer. However, it is not known whether these patterns have attenuated in recent years and whether they are similar for seminomas and nonseminomas, the two main histologic groups of testicular cancer. METHOD Cancer registry data, including 27,030 testicular cancer cases, were...

OBJECTIVE To determine the prevalence, clinical characteristics, management methods and prognosis of testicular cancer at Kenyatta National Hospital. DESIGN Retrospective case study of testicular cancer patients over a fifteen year period. SETTING Kenyatta National Hospital, a referral and teaching hospital. PARTICIPANTS All histologically confirmed testicular cancer patients recorded at ...

PURPOSE To determine the proportion of benign and malignant testicular lesions among patients with nonpalpable incidental testicular masses. METHODS AND MATERIALS Ten patients with nonpalpable incidental testicular masses underwent surgical exploration. Surgery was performed via an inguinal approach with temporary cord occlusion and frozen section examination (FSE) of the lesions. Benign find...

BACKGROUND Advances in oncology have greatly improved the prognosis of testicular cancer. In developing countries, however, the outcome is still poor. PATIENTS AND METHODS Twenty-four patients managed for testicular cancer at two centres (University of Nigeria Teaching Hospital, Enugu, Nigeria, and JAMA Urological Clinic, Enugu) between April 1984 and March 2003 were prospectively studied. Hi...