Light-emission of the perfused lung is induced by t-butyl hydroperoxide, giving chemiluminescence yields that oscillate between 800 and 1500 counts/s depending on the site and position of the lung. The response of the perfused lung to infusion with different hydroperoxides gives a pattern similar to that observed with the liver microsomal fraction; ethyl hydroperoxide shows a much higher chemil...

PURPOSE The main purpose of this study was to investigate the protective role of epigallocatechin-3-gallate on tertiary butyl hydroperoxide induced oxidative damage in erythrocyte during aging in humans. METHODS Human erythrocyte membrane bound Ca(2+)-ATPase and Na(+)/K(+)-ATPase activities were determined as a function of human age. Protective role of epigallocatechin-3-gallate was evaluated...

A simple monocyclic 8n electron thiepin, 2,7-di-tert-butyl-4-ethoxycarbonyl-5-methylthiepin (13) stabilized by two bulky tert-butyl groups at 2and 7-positions, was synthesized from 2,6-di-tert-butyl-4-methylthiopyrylium tetrafluoroborate (11). In spite of of its monocyclic thiepin structure, the compound 13 showed remarkable thermal stability and had a half-life of 7.1 h at 130 °C. Judging from...

The environmental contamination and fate of benzotriazole UV stabilizers (BZTs) have received increasing attention due to their large production volume and wide usage in various consumer and industrial products. In the present work, 60 municipal sewage sludge samples from wastewater treatment plants (WWTPs) in 33 cities in China were collected to investigate the occurrence and distribution of 9...

In searching for opportunities to exploit the benefits of silicon in TRPV1 research, we tried to investigate the pharmacological effects of sila-substitution (C/Si exchange) of tert-butyl group in the MK-056 series. Compound 13a, with a 4-positioned trimethylsilanyl group on the B ring in place of tert-butyl group, exhibited the most potent antagonist activity with IC(50) values of 0.15 microM,...

We report the ambient-temperature synthesis of novel (E)-N-(3-(tert-butyl)-1-methyl-1H-pyrazol-5-yl)-1-(pyridin-2-yl)methanamine 3 in 81% yield by a condensation reaction between 3-(tert-butyl)-1-methyl-1H-pyrazol-5-amine 1 and 2-pyridinecarboxaldehyde 2 methanol using magnesium sulfate as drying agent. The N-pyrazolyl imine was full characterized IR, 1D, 2D NMR spectroscopy, mass spectrometry,...

Covalent grafting of MCM-41 with 3-chloropropyl trimethoxysilane and subsequent reaction respectively with acacdien and complexation with MoO2(acac)2 afforded MoO2acacdien@MCM-41. X-ray diffraction and nitrogen sorption analyses revealed the preservation of the textural properties of the support as well as accessibility of the channel system despite sequential reduction in surface area, pore vo...

We investigated the protective effects of Gymnaster koraiensis against oxidative stress-induced hepatic cell damage. We used two different cytotoxicity models, i.e., the administration of tert-butyl hydroperoxide (t-BHP) and acetaminophen, in HepG2 cells to evaluate the protective effects of G. koraiensis. The ethyl acetate (EA) fraction of G. koraiensis and its major compound, 3,5-di-O-caffeoy...

The synthesis and characterisation of two groups nonsymmetric dimers, the 1-(4-cyanobiphenyl-4‘−yloxy)-ω-(4-butyl, 4-(1-methylpropyl) or 4-t-butylanilinebenzylidene-4’−oxy)alkanes, 1-(4-cyanobiphenyl-4‘−yl)-ω-(4-butyl, are reported. length parity flexible spacer is varied. tert-butyl homologues show higher melting points than corresponding sec-butyl n-butyl substituted suggesting that chain bra...

The reaction of the Schiff base (3,5-di-tert-butyl-2-hydroxybenzylidene)-2-hydroxybenzohydrazide (H3L) with a copper(II) salt of a base of a strong acid, i.e., nitrate, chloride or sulphate, yielded the mononuclear complexes [Cu(H2L)(NO3)(H2O)] (1), [Cu(H2L)Cl]·2MeOH (2) and the binuclear complex [{Cu(H2L)}2(µ-SO4)]·2MeOH (3), respectively, with H2L(-) in the keto form. Compounds 1-3 were chara...