Li, Tianbo, and Hans G. Folkesson. RNA interference for -ENaC inhibits rat lung fluid absorption in vivo. Am J Physiol Lung Cell Mol Physiol 290: L649–L660, 2006. First published October 28, 2005; doi:10.1152/ajplung.00205.2005.—We used siRNA against the -ENaC (epithelial Na channel) subunit to investigate ENaC involvement in lung fluid absorption in rats by the impermeable tracer technique dur...

The use of oxygen-driven aerosol inhalation therapy with budesonide (suspension) and terbutaline sulfate for the treatment of pediatric asthmatic bronchitis was studied. Sixty pediatric patients diagnosed with asthmatic bronchitis in Xuzhou Children's Hospital during the period comprising April 2013 to December 2015 were enrolled in the study. After randomly dividing the patients into a control...

Background and aims—The subtype and species related heterogeneity of â adrenoceptors prompted a functional reappraisal of these molecular targets of motility inhibition in the human colon. Methods—Relaxation of muscle strips was measured in vitro. Results—The following agonists had decreasing relaxing potency (eVective concentration range 10–10 mol/l): (−)isoprenaline (non-selective), terbutali...

Short-acting 2-agonists (SABA) are used in asthma and chronic obstructive pulmonary disease (COPD) treatment because of their capacity to relax smooth muscle, their rapid symptoms relief and their acceptable safety profile. Salbutamol and terbutaline are the most frequently used SABA. Although SABA present an acceptable safety profile as above-mentioned, several adverse effects have been descri...

DescriPtion oF the eviDence collection methoD A critical analysis of articles from the MEDLINE database was carried out using the following keywords (MeSH terms): asthma, asthma/epidemiology, asthma/therapy, oxygen therapy, prednisone, prednisolone, dexamethasone, mineralocorticoids, glucocorticoids, adrenal cortex hormones, bronchodilators, albuterol, terbutaline, fenoterol, salmeterol, formot...

Prolonged treatment with two chemically distinct beta-stimulants, Salbutamol and Terbutaline, resulted in mesovarian leiomyomas in Sprague-Dawley rats. Development of these tumors induced by Salbutamol was prevented by concurrent administration of the beta-blocker Propranolol. Mesovarian leiomyomas induced by Salbutomol did not show any regression or progression during a 44-week postdosing reco...

An account is given of the progress of five patients with intrinsic asthma who have received terbutaline continuously to control airways obstruction over a period of up to 2 years. One aim of this investigation was to find out whether there is any evidence of the development of tachyphylaxis to this drug. No such evidence was found. Two of the patients benefited from the administration of an a-...