Amorphous solids, as well as many disordered lattices, display remarkable universality in their low temperature acoustic properties. This universality is attributed to the attenuation of phonons by tunneling two-level systems (TLSs), facilitated by the interaction of the TLSs with the phonon field. TLS-phonon interaction also mediates effective TLS-TLS interactions, which dictates the existence...

Long-term synaptic change in the cortex and the hippocampus is believed to require the highly localized delivery and translation of mRNAs in the dendritic shafts and spines. The molecular interactions that underlie local signalling between synapses and mRNAs are still largely undefined. After purification from total brain extracts, the NMDA receptor is known to be associated with numerous prote...

DNA lesions, induced by genotoxic compounds, block the processive replication fork but can be bypassed by specialized translesion synthesis (TLS) DNA polymerases (Pols). TLS safeguards the completion of replication, albeit at the expense of nucleotide substitution mutations. We studied the in vivo role of individual TLS Pols in cellular responses to benzo[a]pyrene diolepoxide (BPDE), a polycycl...

While Chip Multiprocessors (CMP) with Thread-Level Speculation (TLS) have become the subject of intense research, processor designers in industry have reservations about their practical implementation. An often cited complaint is that TLS is too energy-inefficient to compete against conventional superscalars. This paper challenges the commonly-held view that TLS is energy inefficient. We identi...

When a replicative DNA polymerase stalls upon encountering a lesion on the template strand, it is relieved by other low-processivity polymerase(s), which insert nucleotide(s) opposite the lesion, extend by a few nucleotides, and dissociate from the 3'-OH. The replicative polymerase then resumes DNA synthesis. This process, termed translesion replication (TLS) or replicative bypass, may involve ...

This document specifies how to establish secure connection-oriented media transport sessions over the Transport Layer Security (TLS) protocol using the Session Description Protocol (SDP). It defines a new SDP protocol identifier, ’TCP/TLS’. It also defines the syntax and semantics for an SDP ’fingerprint’ attribute that identifies the certificate that will be presented for the TLS session. This...

The demand for high-definition surveys within cultural heritage projects represents one of the main factors which promoted the use of laser scanning technology and photogrammetry. By measuring millions of points within relatively short time periods, terrestrial laser scanners allow to derive complete and detailed 3D models of real objects from acquired point clouds. Despite the wide spread of T...

This document specifies how to establish secure connection-oriented media transport sessions over the Transport Layer Security (TLS) protocol using the Session Description Protocol (SDP). It defines a new SDP protocol identifier, ’TCP/TLS’. It also defines the syntax and semantics for an SDP ’fingerprint’ attribute that identifies the certificate that will be presented for the TLS session. This...

TLS is the most important cryptographic protocol in the Internet. At CRYPTO 2012, Jager et al. presented the first proof of the unmodified TLS with ephemeral Diffie-Hellman key exchange (TLS-DHE) for mutual authentication. Since TLS cannot be proven secure under the classical definition of authenticated key exchange (AKE), they introduce a new security model called authenticated and confidentia...

Abstract The anomalous low-temperature properties of glasses arise from intrinsic excitable entities, so-called tunneling Two-Level-Systems (TLS), whose microscopic nature has been baffling solid-state physicists for decades. TLS have become particularly important micro-fabricated quantum devices such as superconducting qubits, where they are a major source decoherence. Here, we present method ...