List of Papers This thesis is based on the following papers, which are referred to in the text by their Roman numerals. Serial sectioning of breast cancer sentinel nodes does not significantly improve false negativity rate. Manuscript. on behalf of the Swedish Breast Cancer Group and the Swedish Society of Breast Surgeons. Axillary recurrence rate 5 years after negative sentinel node biopsy for...

The Rho/ROCK pathway plays important roles in the modulation of the cytoskeletal integrity of cells, the synthesis of extracellular matrix components in the aqueous humor outflow tissue and the permeability of Schlemm's canal endothelial cells. The activation of the Rho/ROCK pathway results in trabecular meshwork (TM) contraction, and the inhibition of this pathway would provoke relaxation of T...

Since the introduction of gentamicin (given both as a soaked sponge and as an injection below Tenon's capsule at the end of surgery) no case of early infection either with or without intraocular signs after operation for retinal detachment has occurred in a series of 206 cases comprising 243 operations. However, late infection many months after operation has appeared in 3 cases (1-5%), though t...

Anaesthesia in ophthalmology has been a popular topic of discussion since the beginnings of the profession. General anaesthesia or sedation paved the way for early ocular surgery until the discovery of cocaine and the development of the hypodermic needle allowed topical and local anaesthetics to gain momentum in the mid-1800s. Almost a century later, improved anaesthetic agents and the addition...

INTRODUCTION Frosted branch angiitis usually occurs in children and presents with severe sheathing of all retinal vessels mimicking the appearance of frosted branches of a tree. OBJECTIVE To report a case of frosted branch angiitis in a pregnant lady. CASE We, hereby, report a case of a 24-year-old pregnant female who presented to us with the complaints of sudden diminution of vision in the...

In order to reduce practice variations and offer cancer patients the best treatments according to reference guidelines, therapeutic decisions have to be taken, in France, by "multidisciplinary staff meetings'' (MSMs) as patient-specific care plans which are then implemented by cancer specialists. OncoDoc2 is a CDSS implementing CancerEst guidelines, a "local reference guideline'', on breast can...

A. Mirand (Clermont-Ferrand), A. Krivine (Cochin, Paris), C. Auvray and A. de Rougemont (Dijon), S. Yerly (Genève), A. Signori-Schmuck (Grenoble), L. Bocket (Lille), S. Rogez (Limoges), C. Tamalet (Marseille), V. Schneider and C. Amiel (Tenon), M. Bouvier-Alias (Mondor), B. Montes (Montpellier), E. Schvoerer (Nancy), V. Ferré (Nantes), M. L. Chaix (Necker, Paris), J. Guinard (Orleans), S. Haim-...