introduction: trastuzumab is a monoclonal antibody that is used in treating breast cancer. we labeled this monoclonal antibody with technetium-99m and performed in vitro and in vivo quality control tests as a first step in the production of a new radiopharmaceutical. methods: trastuzumab was labeled with technetium-99m using succinimidyl hydrazinonicotinamide (hynic) as chelator. radiochemical ...

Primary hyperparathyroidism is increasingly being diagnosed subsequent to the detection of hypercalcaemia using multichannel auto-analyser screening. This paper provides a local picture of the clinical presentation and management of primary hyperparathyroidism. A retrospective review was conducted of 44 patients with primary hyperparathyroidism who were treated at the Queen Elizabeth Hospital b...

Quantitative scintigraphy of proximal interphalangeal joints was performed by a reproducible method using 99m-Technetium in the hands of 40 normal controls and 20 patients with rheumatoid arthritis (RA). The range of the mean uptake varied considerably between proximal interphalangeal (PIP) joints in normal subjects. The mean uptake over PIP joints was not significantly different either between...

The favorable nuclear properties of rhenium-188 for therapeutic application are described, together with new methods for the preparation of high yield and stable 188Re radiopharmaceuticals characterized by the presence of the nitride rhenium core in their final chemical structure. 188Re is readily available from an 188W/188Re generator system and a parallelism between the general synthetic proc...

This study retrospectively reviews 60 cases of primary hyperparathyroidism, 21 of whom underwent technetium 99 sestamibi scanning and 10 of whom underwent thallium 201/technetium 99 pertechnetate scanning preoperatively. The sestamibi and thallium scans demonstrated an 89.5% and a 62.5% sensitivity rate for adenoma, respectively. Neither scan demonstrated hyperplastic glands well. Although the ...

clavicular bone tumors occur in less than 0.5 percent of bone tumors. primary chondrosarcoma is very rare even among clavicle tumors. the main symptom is a touchable mass in 69 % of patients. dedicated centers using fna and cytology can reach a correct diagnosis in 94% of cases. treatment planning is done using simple x-ray, ct-scan, shoulder mri, chest ct-scan, and whole body technetium scan. ...

This first clinical prospective study was conducted to use of technetium-99m immunoglobulin G (99mTc-IgG) as compared with autologous 99mTc-red blood cells (RBC) in gated blood pool ventriculography. We studied 12 patients who referred to us for a possible diagnosis of liver hemangioma or infection. Six patients underwent gated planar blood pool (GPBP) acquisition using 99mTc-RBC and 6 GPBP acq...

sternal non-:union: is a severe complication of sternotomy closure following open heart surgeries. healing problems typically occur in 0.3% to 5% of patients. technetium-99m methylene diphosphonate (99mtc-mdp) bone scintigraphy has been used to assess bone non:union: to predict the healing response for proper management.  in this report, we present the case of a marked sternal non:union: follow...

sternal non-union is a severe complication of sternotomy closure following open heart surgeries. healing problems typically occur in 0.3% to 5% of patients. technetium-99m methylene diphosphonate (99mtc-mdp) bone scintigraphy has been used to assess bone nonunion to predict the healing response for proper management.  in this report, we present the case of a marked sternal nonunion following...