In order to determine the frequency of thyroxine (T4) toxicosis and study the possibility of usefulness for differentiation between thyrotoxic Graves' disease and destructioninduced thyrotoxicosis, the serum concentrations of T4, triiodothyronine(T3), reverse T3 (rT3), and T4-binding globulin (TBG) and the values of T3-uptake and radioactive iodine uptake (RAIU) were measured, and free, T4 inde...

BACKGROUND An increasing number of studies have shown that several ubiquitous environmental contaminants possess thyroid hormone-disrupting capacities. Prenatal exposure to some of them, such as polychlorinated biphenyls (PCBs), has also been associated with adverse neurodevelopmental effects in infants. OBJECTIVES In this study we examined the relationship between exposure to potential thyro...

We examined the effect of endogenous free fatty acids (FFA) on the measurement of free thyroxin (FT4) by five different methodologies represented in 16 different assays in a large number of patients with nonthyroidal illness (NTI). Some, but not all, one-step (analog) FT4 RIAs negatively correlated with FFA concentration. All two-step FT4 RIAs, equilibrium dialysis FT4, and the dialyzable (free...

The dominance of Coulomb interactions over kinetic energy electrons in narrow, non-trivial moir\'{e} bands magic-angle twisted bilayer graphene (TBG) gives rise to a variety correlated phases such as insulators, superconductivity, orbital ferromagnetism, Chern insulators and nematicity. Most these occur at or near an integer number carriers per unit cell. Experimental demonstration ordered stat...

In this Letter we address the reentrance of magic-angle phenomena (band flatness and quantum-geometric transport) in twisted bilayer graphene (TBG) subjected to strong magnetic fluxes $\ifmmode\pm\else\textpm\fi{}{\mathrm{\ensuremath{\Phi}}}_{0},\ifmmode\pm\else\textpm\fi{}2{\mathrm{\ensuremath{\Phi}}}_{0},\ifmmode\pm\else\textpm\fi{}3{\mathrm{\ensuremath{\Phi}}}_{0}...$ (${\mathrm{\ensuremath{...

Rare mutant forms of circulating albumin and prealbumin [transthyretin (TTR)] have increased binding affinity for thyroxine (T4). Patients with these variant plasma proteins, as a result of inherited mutations or as a paraneoplastic phenomenon, typically present with increased serum total T4 and, by some assay methodologies, an increased free T4 as well. Although these individuals are, in fact,...

Hormones have to be transported from their sites of synthesis to their target organs. For lipophilic hormones, such as steroids and thyroid hormones, transport is accomplished by binding to specific serum proteins, in the case of thyroxine (T4) and tri-iodothyronine (T3) to thyroxine-binding globulin (TBG) and prealbumin (PA). Normally about 70% of circulating T4 and 7540% of T3 is bound to TBG...

OBJECTIVE To determine the exact nature and timing of alterations in thyroid function throughout controlled ovarian hyperstimulation (COH). DESIGN Prospective cohort study. SETTING University fertility clinic. PATIENT(S) Fifty-seven women undergoing COH as part of planned in vitro fertilization. INTERVENTION(S) None. MAIN OUTCOME MEASURE(S) Timing and magnitude of change in serum thyr...

Increasing the dimensions of a waveguide provides the simplest means of reducing detrimental nonlinear effects, but such systems are inherently multi-mode, reducing the brightness of the system. Furthermore, using rectangular dimensions allows for improved heat extraction, as well as uniform temperature profile within the core. We propose a method of using the angular acceptance of a transmitti...

We determined binding characteristics of the triiodothyronine (T3) analog tracer used in the Amerlex and Amerlex-M FT3 radioimmunoassay for the three endogenous binding proteins in serum: thyroxin-binding globulin (TBG), thyroxin binding prealbumin (PA), and albumin. Both T3 and its analog bind to the same sites on TBG and PA. However, the analog has significantly lower association constants (1...