The Ag85 complex is a 30-32 kDa family of three proteins (Ag85A, Ag85B, and Ag85C), which all three possess enzymatic mycolyl-transferase activity involved in the coupling of mycolic acids to the arabinogalactan of the cell wall and in the biogenesis of cord factor. By virtue of their strong potential to induce Th1-type immune responses, important for the control of intracellular infections, me...

Adaptive immunity to Mycobacterium tuberculosis controls progressive bacterial growth and disease but does not eradicate infection. Among CD4+ T cells in the lungs of M. tuberculosis-infected mice, we observed that few produced IFN-γ without ex vivo restimulation. Therefore, we hypothesized that one mechanism whereby M. tuberculosis avoids elimination is by limiting activation of CD4+ effector ...

The differences in specificity of human lung and peripheral lymphocytes for mycobacterial antigens (Ag) need to be evaluated in order to identify vaccine candidates against pulmonary tuberculosis (TB). Therefore, the present study examined the response to low molecular weight secretory proteins of Mycobacterium tuberculosis in bronchoalveolar lavage (BAL) and peripheral blood mononuclear cells ...

Most studies of human T-cell responses in tuberculosis have focused on persons with either active disease or latent infection. Although this work has been critical in defining T-cell correlates of successful versus failed host containment, little is known about the development of Mycobacterium-specific T-cell responses in uninfected persons. To explore this issue, naive T cells from uninfected ...

Initiation of an adaptive cellular immune response depends on intimate interactions with APCs and naive T lymphocytes. We previously reported that activation of naive Mycobacterium tuberculosis-specific CD4+ T cells depends on dendritic cell (DC) transport of live bacteria from the lungs to the mediastinal lymph node (MDLN). Because the migratory paths of DCs are largely governed by the chemoki...

ئەم توێژینەوەی بەردەستتان توێژینەوەیەكی ڕۆژنامەنووسییە، كە باس لەڕۆڵی كەسايەتییەكی ڕووناكبیری كورد دەكات لەبواری ڕووناكبیریی و ڕۆژنامەنووسیی كوردیدا، ئەویش زانای ئایینی نووسەر ڕۆژنامەوان (عەلائەددین سەجادی) یە. لەم توێژینەوەیەدا هەردوو گۆڤاری (گەلاوێژ نزار)مان بەنموونە وەرگرتووە، لەبەغداد دەرچووە لەنێوان ساڵانی (1939-1949)دا (واتە: لەماوەی 10 ساڵدا) ناوبراو بەڕێوەبەری نووسین سەرنووسەریان بووە. ...