BACKGROUND The South African Tuberculosis Vaccine Initiative is based in Worcester where tuberculosis (TB) is endemic, and incidence rates are amongst the highest nationally. In high TB burden settings after an early childhood peak, incidence rates start to rise again in adolescents, therefore they are an important target group for tuberculosis vaccine research. In 2012, learners from a local s...

Tuberculosis (TB) is one of the oldest diseases known to mankind, yet it is the second leading cause of death from an infection worldwide today. In the absence of epidemiological data, TB in children was not considered significant and research efforts did not prioritise this group. More recently, there has been renewed interest in childhood TB, leading to improved understanding of the fundament...

In this paper, the interest is in a structured Markov chain model to describe transmission dynamics of tuberculosis (TB) setting small communities hosts sharing confined spaces, and explore potential impact new pre-exposure vaccines on reducing number TB cases during an outbreak disease. The under consideration incorporates endogenous reactivation latent tubercle bacilli, exogenous reinfection ...

objective(s): despite treatment with antibiotics and vaccination with bcg, tuberculosis (tb) is still considered as one of the most important public health problems in the world. therefore, designing and producing a more effective vaccine against tb seems urgently. in this study, immunogenicity of a fusion protein which consisting or comprising cfp-10 from mycobacterium tuberculosis and the fc-...

Tuberculosis (TB) is an old disease. Fragments of the spinal column from Egyptian mummies show evidence of TB over four thousand years ago. Large-scale epidemic of the disease occurred in the recent centuries. In 1958, Grigg pointed out that the shape of the epidemic curve for TB is the same as that for any other infectious disease, if one adjusts the time scale to allow for the roughly 300-yea...

Tuberculosis (TB) and leprosy still represent significant public health challenges, especially in low- and lower middle-income countries. Both poverty-related mycobacterial diseases require better tools to improve disease control. For leprosy, there has been an increased emphasis on developing tools for improved detection of infection and early diagnosis of disease. For TB, there has been a sim...

Introduction : One of the top 10 causes death worldwide is tuberculosis (TB). An estimated million new cases TB, including 1.2 in children, were reported 2019. Due to symptoms pediatric (TB) being similar those other juvenile illnesses and difficulty obtaining lung samples due children's propensity swallow sputum, diagnosing TB challenging. Methods This systematic review's objective was find re...

Mycobacterium tuberculosis infects one third of the world's population. Due to variable efficacy of the Bacille Calmette Guerin (BCG) vaccine, development of novel TB vaccines remains a priority. Here, we demonstrate the protective efficacy of a novel multivalent DNA vaccine, which contains 15 synthetic antigens targeting the Mtb ESX secretion system.

In an accident later known as the Lübeck disaster, 251 neonates were orally given three doses of the new Bacille Calmette-Guérin (BCG) antituberculosis (TB) vaccine contaminated with Mycobacterium tuberculosis. A total of 173 infants developed clinical or radiological signs of TB but survived the infection, while 72 died from TB. While some blamed the accident on BCG itself by postulating rever...

objective: despite using the bacille calmette guerin (bcg) vaccine, tuberculosis (tb) is still a worldwide disease that kills 2-3 million people each year. developing a new and more effective vaccine is one way to possibly reduce the morbidity and mortality of tb. the mtb72f vaccine is one of the important subunit vaccines applied in human clinical trials. in this study, we have constructed an ...