نتایج جستجو برای: tau hyperphosphorylation

تعداد نتایج: 21929  

2009
Shreyasi Chatterjee Tzu-Kang Sang George M. Lawless George R. Jackson

Hyperphosphorylation of tau at multiple sites has been implicated in the formation of neurofibrillary tangles in Alzheimer's disease; however, the relationship between toxicity and phosphorylation of tau has not been clearly elucidated. Putative tau kinases that play a role in such phosphorylation events include the proline-directed kinases glycogen synthase kinase-3beta (GSK-3beta) and cyclin-...

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Journal: :Human molecular genetics 2012
Emma Richet Amy M Pooler Teresa Rodriguez Sergey S Novoselov Gunter Schmidtke Marcus Groettrup Diane P Hanger Michael E Cheetham Jacqueline van der Spuy

Abnormal phosphorylation of the microtubule-associated protein tau in neurodegenerative disorders, including Alzheimer's disease (AD) and frontotemporal lobar degeneration, is associated with disrupted axonal transport and synaptic dysfunction ultimately manifesting as histopathological lesions of protein aggregates. Glycogen synthase kinase 3β (GSK3β) may be critical for the pathological hyper...

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Journal: :Experimental neurology 2014
Ioannis Sotiropoulos André T Lopes Vitor Pinto Sofia Lopes Sara Carlos Sara Duarte-Silva Andreia Neves-Carvalho Filipa Pinto-Ribeiro Sara Pinheiro Rui Fernandes Armando Almeida Nuno Sousa Hugo Leite-Almeida

Tau protein hyperphosphorylation and consequent malfunction are hallmarks of Alzheimer's disease pathology; importantly, pain perception is diminished in these patients. In physiological conditions, Tau contributes to cytoskeletal dynamics and in this way, influences a number of cellular mechanisms including axonal trafficking, myelination and synaptic plasticity, processes that are also implic...

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Journal: :BMB reports 2010
Jongyeon Shin Saet-Byeol Yu Un Young Yu Sangmee Ahn Jo Jung-Hyuck Ahn

The Swedish mutation (K595N/M596L) of amyloid precursor protein (APP-swe) has been known to increase abnormal cleavage of cellular APP by Beta-secretase (BACE), which causes tau protein hyperphosphorylation and early-onset Alzheimer's disease (AD). Here, we analyzed the effect of APP-swe in global gene expression using deep transcriptome sequencing technique. We found 283 genes were down-regula...

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Journal: :The American journal of pathology 2009
Chad Dickey Clara Kraft Umesh Jinwal John Koren Amelia Johnson Laura Anderson Lori Lebson Daniel Lee Dennis Dickson Rohan de Silva Lester I Binder David Morgan Jada Lewis

We have extensively analyzed the biochemical and histochemical profiles of the tau protein from the rTg4510 transgenic mouse model in which the animals uniquely develop forebrain tau pathologies similar to those found in human tauopathies. Levels of several soluble phosphorylated tau species were highest at 1 month relative to later time points, suggesting that certain tau hyperphosphorylation ...

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Journal: :Neurobiology of Disease 2019

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2012
Sônia A. L. Corrêa Katherine L. Eales

A significant amount of evidence suggests that the p38-mitogen-activated protein kinase (MAPK) signalling cascade plays a crucial role in synaptic plasticity and in neurodegenerative diseases. In this review we will discuss the cellular localisation and activation of p38 MAPK and the recent advances on the molecular and cellular mechanisms of its substrates: MAPKAPK 2 (MK2) and tau protein. In ...

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Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2006
Chad A Dickey Mei Yue Wen-Lang Lin Dennis W Dickson Judith H Dunmore Wing C Lee Cynthia Zehr Gemma West Songsong Cao Amber M K Clark Guy A Caldwell Kim A Caldwell Christopher Eckman Cam Patterson Michael Hutton Leonard Petrucelli

Accumulation of the microtubule-associated protein tau into neurofibrillary lesions is a pathological consequence of several neurodegenerative diseases, including Parkinson's disease and Alzheimer's disease. Hereditary mutations in the MAPT gene were shown to promote the formation of structurally distinct tau aggregates in patients that had a parkinsonian-like clinical presentation. Whether tau...

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Journal: :Journal of Neuroinflammation 2016

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Journal: :Frontiers in Aging Neuroscience 2018

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