Protein tau-3R/4R isoform ratio and phosphorylation regulates binding to microtubules and, when disturbed by aging or mutations, results in diverse tauopathies and in neurodegeneration. The underlying mechanisms were studied here in three transgenic mouse strains with identical genetic background, all expressing the tau-4R/2N isoform driven specifically in neurons by the thy1 gene promoter. Two...

Machine learning has been successfully applied to various fields of scientific computing in recent years. In this work, we propose a sparse radial basis function neural network method solve elliptic partial differential equations (PDEs) with multiscale coefficients. Inspired by the deep mixed residual method, rewrite second-order problem into first-order system and employ multiple networks (RBF...

This Fifth International WEIN Symposium is devoted to physics beyond the standard model. This talk is about tau lepton physics, but I begin with the question: do we know how to nd new physics in the world of elementary par-ticles? This question is interwoven with the various tau physics topics. These topics are: searching for unexpected tau decay modes; searching for additional tau decay mechan...

Recent evidence suggests that tau aggregates are not only neurotoxic, but also propagate in neurons acting as a seed for native tau aggregation. Prion-like tau transmission is now considered as an important pathogenic mechanism driving the progression of tau pathology in the brain. However, prion-like tau species have not been clearly characterized. To identify infectious tau conformers, here w...

$\mbox{CP}$-odd asymmetries in the processes $e^+e^-\rightarrow \tau^+\pi^-\nu_\tau$, \pi^+\tau^-\bar\nu_ \tau$, \tau^+\rho^-\nu_\tau$, \rho^+\tau^-\bar\nu_\tau $, $e^+e^-\to \tau^+e^-\nu_\tau{\bar\nu}_e\,,\,$ and $\,e^+e^-\to \tau^-e^+\nu_e{\bar\nu}_\tau$ are investigated with account for longitudinal polarization of electron (or positron) beam. These is a manifestation electric dipole form fa...

Abstract Port-based teleportation (PBT) is a protocol that employs number of Bell pairs and joint measurement to enact an approximate input-output identity channel. Replacing the with different multi-qubit resource state changes enacted channel allows PBT simulate qubit channels beyond identity. The resulting from using general consequently interest. In this work, we fully characterise Choi mat...

Tau aggregation is a hallmark of several neurodegenerative diseases, including AD (Alzheimer's disease), although the mechanism underlying tau aggregation remains unclear. Recent studies show that the proteolysis of tau plays an important role in both tau aggregation and neurodegeneration. On one hand, truncation of tau may generate amyloidogenic tau fragments that initiate the aggregation of t...

The detection of motion from image sequences is usually performed using a time differential method or calculating the difference from a background reference image. These algorithms often perform poorly in the presence of temporal clutter. This paper describes a technique that measures the irregularity of an intensity sequence to detect motion. We demonstrate that static background, interesting ...

Phosphorylated forms of microtubule-associated protein tau accumulate in neurofibrillary tangles in Alzheimer's disease. To investigate the effects of specific phosphorylated tau residues on its function, wild type or phosphomutant tau was expressed in cells. Elevated tau phosphorylation decreased its microtubule binding and bundling, and increased the number of motile tau particles, without af...