Rheumatoid arthritis (RA) is an autoimmune disease which has a significant socio-economic impact. The aim of the current study was to investigate eight candidate RA susceptibility loci to identify the associated variants in Egyptian population. Eight single nucleotide polymorphisms (SNPs) (MTHFR-C677T and A1298C, TGFβ1 T869C, TNFB A252G, and VDR-ApaI, BsmI, FokI, and TaqI) were tested by genoty...

We have reinvestigated a classification of clinical heterogeneity among cystic fibrosis (CF) patients that we previously reported and investigated the possible relationship of the identified CF subgroups to haplotypes around the CF gene and to HLA-DR haplotypes. Age-corrected values for sweat electrolytes, rate of progression of lung disease as assessed by Brasfield chest x-ray scores, and seve...

Graves’ (GD) hyperthyroidism induces accelerated bone turnover that leads to decreased bone mineral density (BMD). The role of the VDR gene in predisposition to primary osteoporosis has been recognized. Recent studies show associations between the VDR gene polymorphisms and susceptibility to autoimmune diseases. Here we analyzed if VDR gene polymorphisms: BsmI, ApaI, TaqI, and FokI may predispo...

BACKGROUND Vitamin D deficiency and vitamin D receptor gene polymorphisms are known to be significantly associated with high myopia. Whether this genetic variant may impact primary open-angle glaucoma is largely unknown. This study investigated whether vitamin D receptor gene polymorphisms are altered in primary open-angle glaucoma subjects carrying the risk allele, and whether vitamin D defici...

Objective: The effect of MYF5 gene polymorphism on body weight was investigated in 100 Friesian bull calves. Methodology: Blood samples were collected from each animal for DNA extraction. The PCR-TaqI digestion of 1190 bp of a fragment of MYF5 gene revealed that, two fragments (983 and 207 bp) for genotype BB, three fragments (1190, 983 and 207 bp) for genotype AB and undigested fragment (1190 ...

Vitamin D(3) is a neurosteroid that mediates its effects via the vitamin D receptor (VDR). The VDR gene is located on chromosome 12q13 and consists of 9 exons. VDR contains the DNA-binding site encoded by exons 2 and 3 and the ligand-binding site encoded by exons 4 - 9. Our earlier study showed that the ApaI polymorphic site of the VDR gene is associated with late-onset Alzheimer's disease (...

Fifty-six hybrids of Tossa jute (Corchorus olitorius L.) were raised at Hajee Mohammad Danesh Science and Technology University, Dinajpur from the parental lines O-9897, O-795, JRO-524, Acc.-2381, Acc.-3423, Acc.-3438, Acc.-3533 Acc.-3860 studied. Maximum 24 genotypes in cluster II followed by 11 I, 9 IV, 6 VI, 4 V only 2 IV minimum (2.871) was between clusters V. Cluster VI produced highest me...