Tanshinone IIA (Tan-IIA) is extracted from Danshen and known to inhibit proliferation and induce apoptosis in many cancer cells. We aimed to elucidate its anticancer activity and molecular mechanism in human lung cancer A549 cells. The cytotoxicity of Tan-IIA in A549 cells were measured by the MTT assay. The effects of Tan-IIA on the cell cycle, mitochondrial membrane potential (MMP), calcium a...

Tanshinone IIA (Tan-IIA) is extracted from Danshen, Salviae miltiorrhizae Radix, which has been widely adopted in traditional herbal medicine to treat cardiovascular and hepatic diseases. Tan-IIA induces apoptosis and inhibits proliferation in human hepatocellular carcinoma (HCC) cells. However, the molecular mechanisms of Tan-IIA on human HCC cells are not understood clearly. In the present st...

Present study was conducted to determine the dry mass and the total ammonia-N (TAN) excretion in embryos, Zoea (I–XI) and post-larvae (PL) stages of Macrobrachium rosenbergii at 1, 5, and 10 d after metamorphosis (PL1, PL5, and PL10). Tested animals were collected according to their developmental stages, and placed into incubation chambers (∼50 mL) for 2 hours to calculate the TAN excretion of ...

Tanshinone IIA (Tan IIA) is one of the major fat-soluble ingredients in Salvia miltiorrhiza which has been widely used for various inflammatory conditions associated with cardiovascular and cerebrovascular disorders. However, the underlying anti-inflammatory mechanisms of Tan IIA are incompletely understood. The purpose of this study was to illuminate the anti-inflammatory mechanism of Tan IIA ...

In this letter, we propose a novel low-temperature nitridation technology on a tantalum nitride (TaN) thin film resistor (TFR) through supercritical carbon dioxide (SCCO2) treatment for temperature sensor applications. We also found that the sensitivity of temperature of the TaN TFR was improved about 10.2 %, which can be demonstrated from measurement of temperature coefficient of resistance (T...

If tan β is large, supersymmetric QCD corrections can become large, putting naive perturbation theory into doubt. I show how these tan β-enhanced corrections can be controlled to all orders in αs tan β. The result is shown for the decays H + → tb and b → sγ. 1 Large corrections to all orders The Minimal Supersymmetric Standard Model (MSSM) contains two Higgs doublets H u and H d. Their neutral ...

The aim of present study is to elucidate autophagic mechanism of tanshinone I (Tan I) in H28 and H2452 mesothelioma cells. Herein, Tan I exerted cytotoxicity with autophagic features of autophagy protein 5 (ATG5)/ microtubule-associated protein 1A/1B-light chain 3II (LC3 II) activation, p62/sequestosome 1 (SQSTM1) accumulation and increased number of LC3II punctae, acridine orange-stained cells...

The zirconia stabilized by 3mol % Y2O3 (3YSZ) was applied onto the surface of the magnesium alloy AZ91D using electrophoretic deposition (EPD) from a non- aqueous solution. A Ni-P interlayer between the substrate and YSZ coating was also prepared by electroless plating. Finally, coatings were heat treated in control atmosphere at 400 °C. The preparation, microstructure and corrosion resistance ...