The calcineurin/NFAT signaling pathway is implicated in a wide variety of biological processes, acting as a bridge pathway between calcium signals and gene expression. Although its role as an effector of immune responses figured prominently in early studies, it forms just one part of a larger picture. Indeed calcineurin has been shown to participate in the development and function of e.g. the i...

The human cytotoxic T-cell line TALL-104 displays antitumor effects in animals with implanted and spontaneous malignancies. A Phase I trial was conducted to determine toxicity of TALL-104 cell therapy in women with metastatic refractory breast cancer. Fifteen patients with metastatic infiltrating ductal (n = 12), lobular (n = 2), or medullary (n = 1) carcinoma received escalating doses of letha...

Invasive species may owe some of their success in competing and co-existing with native species to microbial symbioses they are capable of forming. Tall fescue is a cool-season, non-native, invasive grass capable of co-existing with native warm-season grasses in North American grasslands that frequently experience fire, drought, and cold winters, conditions to which the native species should be...

Plant functional traits are thought to drive variation in primary productivity. However, there is a lack of work examining how dominant species identity affects trait-productivity relationships. The productivity of 12 pasture mixtures was determined in a 3-year field experiment. The mixtures were based on either the winter-active ryegrass (Lolium perenne) or winter-dormant tall fescue (Festuca ...

Heat stress is a major problem in transporting stocker calves with symptoms of fescue toxicosis. Removing calves from tall fescue pastures and offering diets devoid of endophyte-infected tall fescue could reduce the severity of toxicosis and precondition calves for transport to the feedlot. In the present experiment, a pasture phase was used to condition yearling steers to grazing tall fescue a...

Tall fescue (Festuca arundinacea Schreb.) is an important cool-season perennial grass species used as forage and turf, and in conservation plantings. There are three morphotypes in hexaploid tall fescue: Continental, Mediterranean and Rhizomatous. This study was conducted to develop morphotype-specific molecular markers to distinguish Continental and Mediterranean tall fescues, and establish th...

A nkyrin proteins organize the plasma membrane into specialized domains by binding to trans-membrane proteins and anchoring them to a submembranous network of spectrin and actin (1). Ankyrin-G, for example, helps build the axon initial segment of neurons and also promotes assembly of the lateral membrane of columnar epithelial cells (2). He et al. reveal that lipids play an essential role in ta...

We present a formal account of the meaning of vague scalar adjectives such as ‘tall’ formulated in Type Theory with Records. Our approach makes precise how perceptual information can be integrated into the meaning representation of these predicates; how an agent evaluates whether an entity counts as tall; and how the proposed semantics can be learned and dynamically updated through experience.

One-third of American pediatric endocrinologists offer growth-suppression treatments for tall girls despite serious medical risks and little or no evidence of benefit to psychosocial functioning. A survey of 59,632 adults shows that most tall women are satisfied with their height, which raises questions about the continued use of growth-suppression treatments.

In this paper, a two-stage method for damage detection and estimation in tall shear frames is presented. This method is based on the first mode shape of a shear frame. We demonstrate that the first mode shape slope is very sensitive to the story stiffness. Thus, at the first stage, by using the grey system theory on the first mode shape slope, damage locations are identified in shear frames. Da...