Designer transcription-activator like effectors (TALEs) is a promising technology and made it possible to edit genomes with higher specificity. Such specific engineering and gene regulation technologies are also being developed using RNA-binding proteins like PUFs and PPRs. The main feature of TALEs, PUFs and PPRs is their repetitive DNA/RNA-binding domains which have single nucleotide binding ...

Xanthomonas TALE transcriptional activators act as virulence or avirulence factors by activating host disease susceptibility or resistance genes. Their specificity is determined by a tandem repeat domain. Some Xanthomonas pathogens contain 10-30 TALEs per strain. Although TALEs play critical roles in pathogenesis, their studies have so far been limited to a few examples, due to their highly rep...

One of the manifestations culture and civilization even literature any country is proverbs, rulings short rich words that arise from greats science or common people in our vast ancient language there are thousands proverbs Which has taste, thought kindness good interpretation saying meaning. The a society, when they find their experiences reserves those past as accepted certain facts, express t...

In Japan, most of children haven’t read children’s story (Fairy tales or tales of old Japan) because the high technology video games are more exciting than most of picture books. But they must be effective to bring up the children’s cultivation of aesthetic sensitivity. And we have heard from teachers of elementary schools that most of themes of computer education in school are the operation of...

In this paper we argue that digital games have come to fill the cultural niche traditionally occupied by fairy tales, and that they are ideally suited to realize some of the unique characteristics of this genre of folklore and literature. One of the most influential authors of fantasy narrative, J.R.R. Tolkien, wrote extensively about fairy tales, authored fairy tales and considered his great e...