In today's changing conditions, there has been an increase in the consumption of ready-made food with change eating habits. Moreover, parallel to production, additives used. The dose amounts are determined as a result experimental analyses. However, some show long-term toxic effects on human body genotoxicity tests. this review, definition substances, purposes usage, classification, genotoxicit...

The interaction of polyamine conjugates with DNA double helix has been studied. Binding properties were examined by ethidium bromide (EtBr) displacement and DNA unwinding/topoisomerase I/II (Topo I/II) activity assays, as well as dsDNA thermal stability studies and circular dichroism spectroscopy. Genotoxicity of the compounds was estimated by a comet assay. It has been shown that only compound...

PURPOSE To determine the effect of petrol exposure on DNA integrity in peripheral blood lymphocytes among petrol attendants and a non-exposed comparison population. METHODS This cross-sectional study included 101 fuel station employees and 50 office-based non-exposed workers in Durban, South Africa. Participants were interviewed using a validated questionnaire. Genomic DNA was extracted from ...

BACKGROUND Most of herbal medicines are used without any standard safety and toxicological trials although common assumption is that these products are nontoxic. However, this assumption is incorrect and dangerous, so toxicological studies should be done for herbal drugs. Although Pterolobium stellatum, Otostegia integrifolia and Vernonia amygdalina root extracts are frequently used in Ethiopia...

Genotoxicity in wastewater and reclaimed water now is gaining increased attention because of genotoxins' potential damage to the ecosystem and human health. The effect of ozonation on genotoxicity in reclaimed water was investigated. It was found that ozonation decreased the genotoxicy dramatically in three tertiary treatment plants. In the further batch ozonation experiment in laboratory, seco...

The increase in consumption of herbal liquors Nigeria is a cause for alarm. These are consumed with the mis-conception that they without toxic effects. aim this study to investigate genotoxic and histopathological alterations rats exposed liquors. Female were 6 weeks. evaluation done assess extent damage. Pathological examination revealed incidences aggregates chronic inflammatory cell infiltra...

Coexposure to heavy metals occurs in many occupational settings, such as automobile refining shops, pigment, and batteries production. Heavy metals around automobile refining shops were tested for their ability to induce synergistic cytogenetic effects in Trifolium repens L. by using the chromosomal aberrasions (CAs), micronucleus (MN) and comet assay. A significant increase in micronucleus (MN...

This paper presents an approach for the reliability–based design optimization of highly safe structural systems where a tail–model is used for computing the reliability constraint during design optimization. It is generally accepted that using central models (e.g., moment– based method or stochastic response surfaces) for estimating large percentiles such as those required in reliability constr...

This paper proves weak convergence in D of the tail empirical process – the renormalized extreme tail of the empirical process – for a large class of stationary sequences. The conditions needed for convergence are (i) moment restrictions on the amount of clustering of extremes, (ii) restrictions on long range dependence (absolute regularity or strong mixing), and (iii) convergence of the covari...

• Pre-validation study on comet assay for detecting site of contact genotoxicity. Acrylic implants containing EMS (AF + EMS) was used as test item. AF showed DNA damage at using whereas negative Ames and chromosome aberration test. Implants may cause ‘site genotoxicity’ without systemic Comet has potential use in medical device biocompatibility assessment. Toxicological risk assessment devices ...