The treatment for erectile dysfunction (ED) was revolutionized with the development of phosphodiesterase type 5 (PDE5) inhibitors. Tadalafil (Cialis((R)); Eli Lilly and Company, Indianapolis, IN, USA) is the newest and most versatile PDE5 inhibitor in the clinical armamentarium for the treatment of ED. Its most unique characteristic is its long half-life of 17.5 hours, which lends itself to a l...

A. Alpha adrenergic blockers (alfuzosin, doxazosin, silodosin, tamsulosin, and terazosin) B. Hormonal manipulation (including finasteride, dutasteride, and dutasteride plus tamsulosin) C. Interstitial laser coagulation of the prostate (ILCP) D. Laser prostatectomy E. Laser based procedures including contact laser ablation of the prostate (CLAP), holmium laser procedures of the prostate (HoLAP, ...

Case Report A 48-year-old man presented with sudden memory impairment. His medical history was relevant for mild dyslipidemia and long-standing impotence. Tadalafil had been prescribed for the first time the day before. After taking a 25 mg pill, and not getting an erection, he decided to sleep. He was not anxious, did not hyperventilate, and did not undergo any physical activity before sleepin...

Objective: During drug preformulation studies, thermal analysis and spectroscopic techniques are used to detect physical or chemical incompatibilities between the active compound excipients in formulation, demonstrate safety and/or efficacy of final product. It has revolutionized erectile dysfunction with development a selective cyclic guanosine monophosphate-specific PDE-5 inhibitors. Tadalafi...

AbstractThe circulation of candy with tadalafil content in the community needs a serious attention by BPOM. The product that is circulating closely related to distribution permit. has not been registered BPOM because it listed list drugs already have permission from manufacturer or importer and must be examined legal status product. This study tries explain legality products extent BPOM's respo...

Due to the active role of estrogen receptor α (ERα) in certain breast cancer, finding possible ERα antagonists is important for lowering growth rate ERα-motivated cancer cells. Here, current work was conducted computationally find inhibitors based on use docking methods. The three-dimensional (3D)-ERα structure freely docked with 3D ligands, including milbemycin_A3_5-oxime (MA), Baloxavir marbo...