Pneumonitis is a serious and unpredictable side-effect of treatment with methotrexate (MTX) that may become life-threatening. The clinical and histological features of nine cases of MTX pneumonitis are reported and the literature reviewed. The typical clinical symptoms include progressive shortness of breath and cough, often associated with fever. Hypoxaemia and tachypnoea are always present an...

Most patients with urea cycle disorders who present as neonates, do so with deteriorating feeding, drowsiness and tachypnoea, following a short initial period when they appear well. The plasma ammonia should be measured at the same time as the septic screen in such patients. Ammonia levels above 200 micromol/l are usually caused by inherited metabolic diseases and it is essential to make a diag...

The clinical and morphological features are presented of eight infants who developed a chronic respiratory illness in the first year of life characterised by tachypnoea and inspiratory crackles on auscultation. The median age at the onset of symptoms was 1 month (range 1 day to 7 months). Five of the infants required supplemental oxygen. Chest radiographs showed only non-specific perihilar alve...

To cite: Veltcamp Helbach M, Savelkoul C, Festen-Spanjer B, et al. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2016216738 DESCRIPTION An 83-year-old woman with Crohn’s disease presented at the emergency department with severe abdominal pain. Diagnostic colonoscopy confirmed sigmoid stenosis and pneumodilatation was performed. Post procedure the patient develop...

BACKGROUND The first reported case of intestinal perforation secondary to metastatic lung carcinoma was reported in 1957. Intestinal metastases are present in up to 1.8% of the cases, with small bowel obstruction as the most common clinical presentation. CLINICAL CASE An 89 year-old male, who was diagnosed with a high-grade pulmonary mucoepidermoid tumour 2 months previously. The patient was ...

BACKGROUND/AIM Hypoxia and carbon dioxide rebreathing are potential problems during eye surgery in spontaneously breathing patients. The aim of the present study was to determine effectiveness of nasal application of oxygen to prevent hypoxia and carbon dioxide accumulation in spontaneously breathing patients undergoing cataract surgery. METHODS Oxygenation and carbon dioxide rebreathing were...

The measurement of the mechanical work of breathing (WOB) has been used in clinical research for over four decades and has provided valuable insights into the pathophysiological derangements that exist in patients with chronic obstructive pulmonary disease (COPD). These WOB calculations are based on the principle that work is performed when pressure changes the volume of the respiratory system....

OBJECTIVE Parent-reported symptoms are frequently used to triage children, but little is known about which symptoms identify children with serious respiratory infections. The authors aimed to identify symptoms and triage findings predictive of serious respiratory infection, and to quantify agreement between parent and nurse assessment. DESIGN Prospective diagnostic cohort study. SETTING Pae...

Background: Tobacco use is a major public health problem globally. According to the World Health Organization (WHO), tobacco second most important cause of death in world. It currently estimated be responsible for about 5 million deaths each year worldwide. In India, it over 8 lakh every year. one preventable causes disease and globally.Aims study: To determine occupational hazard workers.Objec...

Madam, Transfusion of blood products is a life rescuing medical intermediation; however, associated adverse transfusion reactions are major pitfalls. Transfusion-associated circulatory overload (TACO) life-threatening pulmonary oedema that develops secondary to volume overload. Underlying precipitating factors include ages >60 years or <3 years, low body mass index (BMI), rapid rate and p...