Every year the Swedish Institute for Computer Science (SICS) holds the Trading Agent Competition (TAC). Although the specifications of the competition vary from year to year, the classic game is continually maintained. In this paper, I present a search-based approach to playing the TAC Classic game. I will show the background of the game and present the rules of TAC classic, review the state of...

Cyclosporine A (CsA) and tacrolimus (Tac) are immunosuppressive drugs used in the majority of patients with solid organ transplants, generally in combination with a wide range of drugs. CsA and Tac seem not only to be substrates of CYP3A but have also been described as inhibitors of CYP3A. For CsA, in particular, inhibition of CYP3A has been suggested as the main mechanism of interactions seen ...

Interleukin 2 (IL-2) induced activation of unstimulated resting natural killer (NK) cells or resting T-cells initially occurs following binding of IL-2 through the p75 receptor that is expressed primarily by these cells. However, this IL-2/p75 interaction induces TAC chain synthesis and formation of high affinity IL-2 receptor required for the proliferation of resting peripheral blood lymphocyt...

Evidence from epidemiologic studies has shown that total antioxidant capacity (TAC) in the diet might be inversely associated with stroke, heart failure, and inflammatory biomarkers. However, studies on the association of TAC from both diet and supplements with cardiovascular disease (CVD) risk factors in the U.S. population are lacking. This cross-sectional population-based study aimed to inve...

BACKGROUND Tacrolimus (TAC) to ciclosporin A (CSA) conversion studies in stable kidney transplant recipients have reported varying effects on graft function. Here we study graft function (eGFR) trajectories using linear mixed models, which provide effect estimates on both slope and baseline level of GFR and offer increased statistical power. METHODS Secondary analysis of a randomized controll...

BACKGROUND AND AIMS At Saitama Medical Center, for remission induction in active ulcerative colitis (UC) patients with endoscopic evidence of severe disease, we tend to preferentially use tacrolimus (TAC) over anti-tumor necrosis factor (TNF)-α agents. We conducted this study to evaluate the validity of our therapeutic strategies. PATIENTS AND METHODS This retrospective study was conducted in...

QUESTIONS UNDER STUDY The aim of this study was to evaluate risk factors and outcome of expanded-criteria donor (ECD) kidney transplants in patients with low immunological risk. METHODS We evaluated graft survival and graft function in 265 recipients with low immunological risk defined as the absence of pretransplant donor-specific HLA antibodies. RESULTS A total of 112 (42%) kidneys derive...

BACKGROUND We compared docetaxel plus doxorubicin and cyclophosphamide (TAC) with fluorouracil plus doxorubicin and cyclophosphamide (FAC) as adjuvant chemotherapy for operable node-positive breast cancer. METHODS We randomly assigned 1491 women with axillary node-positive breast cancer to six cycles of treatment with either TAC or FAC as adjuvant chemotherapy after surgery. The primary end p...

In their nice study on serum total antioxidant capacity (TAC) in sepsis [1] Chuang and coworkers have demonstrated an increase in TAC that was directly correlated to severity of illness and poor outcome, and to increasing levels of serum uric acid (UA). Although the increase in TAC might be interpreted as an extreme protective attempt against overwhelming inflammation, this must still be proved...

Data of several laser-induced incandescence (LII) experiments reported in the literature were re-analyzed to obtain the values of the thermal accommodation coefficient (TAC) of soot. The present analysis shows that the TAC of soot falls in a relatively narrow range between 0.23 (in N2 and flames) and 0.45 (in Argon). Using an aggregate based lowfluence LII model, the TAC of soot in a laminar di...