statement of the problem: the bond strength of composites with different adhesive systems with dentin is an important factor in long term durability of composite restorations. the effect of titanium tetrafluoride (tif4) as anti caries agent and sodium hypochlorite (naocl) as disinfectant on the shear bond of nanofilled and silorane based composite resins have not been investigated in previous s...

abstract: introduction: ditching and marginal defects of amalgam restorations can cause microleakage, recurrent carries, pulp hypersensitivity and finally loss of the tooth. the complete replacement of large restoration is time consuming, difficult and may potentially damage the pulp. therefore in cases were there is no sings of recurrent caries, composite repair can be chosen as an alternative...

because of inhomogeneity and anisotropy of composite materials, defining a unique fatigue criterion to be suitable for different loading conditions is much more difficult in comparison with traditional materials. for this reason many tests on evaluating the damages such as crack density, stiffness reduction and residual strength are used by various researchers to monitor the fatigue process. in...

background and aims. effect of surface treatments on repair bond strength of aged composite resins might be different due to their dissimilar fillers. the aim was to evaluate the effect of different surface treatments on repair micro-shear bond strength (µsbs) of silica- (spectrum tph) and zirconia-filled (filtek z250) composite resins. materials and methods. twenty-seven composite resin blocks...

objective: selection of an appropriate shade of composite is critical in achieving an esthetic restoration. different systems are used to assess and describe color parameters. this study aimed to assess the effect of color and thickness of filtek supreme (fs) and premise (p) composite resins on correction of tooth discoloration.   methods: in this in vitro experimental study, 10 anterior teeth ...

background and aim: in vitro studies have revealed a direct association between resin content and cytotoxicity of resin composites; but implantation studies in this regard are sparse. this study investigates the relationship between filler content of composite resins and biocompatibility. materials and methods: this study was conducted using 18 male wistar rats (180-200g), 1 nano-hybrid (prime-...

NF-jB-dependent immune responses are tightly controlled so as to avoid runaway inflammation. One easy model to study the negative regulation of these pathways is provided by the Drosophila melanogaster immune deficiency (IMD) pathway, which regulates both systemic and epithelial immune responses against bacteria. Ragab et al (2011) report in this issue of the EMBO Journal that the Ras/ MAPK pat...

The protein kinase PINK1 was recently shown to phosphorylate ubiquitin (Ub) on Ser65, and phosphoUb activates the E3 ligase Parkin allosterically. Here, we show that PINK1 can phosphorylate every Ub in Ub chains. Moreover, Ser65 phosphorylation alters Ub structure, generating two conformations in solution. A crystal structure of the major conformation resembles Ub but has altered surface proper...

Spontaneous immune tolerance in mouse liver transplantation has always been a hotspot in transplantation-immune research. Recent studies revealed that regulatory T cells (Tregs), hepatic satellite cells and Kupffer cells play a potential role in spontaneous immune tolerance, however the precise mechanism of spontaneous immune tolerance is still undefined. By using Microarray Chips, we investiga...

Gemifloxacin (GMF) is an orally administered broad-spectrum fluoroquinolone antimicrobial agent used to treat acute bacterial exacerbation of pneumonia and bronchitis. Although fluoroquinolone antibiotics have also been found to have anti-inflammatory and anticancer effects, studies on the effect of GMF on treating colon cancer have been relatively rare. To the best of our knowledge, this is th...