In this paper, we proposed an automatic spherical maze generation framework. Traditional mazes are generated on two or three dimensional spaces, with regular grids as walls and paths. Instead of pure two or three dimensional mazes, we automatically generate maze on the surface of a sphere, which provides a unique and fresh maze solving experience. Because regular grids on spherical surface will...

AIMS The number of approved drugs for the clinical treatment of Alzheimer disease remains limited. For this reason, there is extensive search for novel therapies. Of these, cholinesterase inhibitors have some proven benefit in slowing the disease progression and still remain the first-line therapeutic approach. In this study, the pro-cognitive effect of four novel tacrine-related inhibitors was...

Aims. The number of approved drugs for the clinical treatment of Alzheimer disease remains limited. For this reason, there is extensive search for novel therapies. Of these, cholinesterase inhibitors have some proven benefit in slowing the disease progression and still remain the first-line therapeutic approach. In this study, the pro-cognitive effect of four novel tacrine-related inhibitors wa...

Working memory is an executive function that is highly dependent on the functioning of the prefrontal cortex. Several studies using food or drink as rewards have demonstrated that rats are capable of performing tasks that involve working memory. Sexual behavior is another highlyrewarding, motivated behavior that has proven to be an efficient incentive in classical operant tasks. Considering tha...

The goal of this review is to discuss how behavioral tests in mice relate to the pathological and neuropsychological features seen in human Alzheimer's disease (AD), and present a comprehensive analysis of the temporal progression of behavioral impairments in commonly used AD mouse models that contain mutations in amyloid precursor protein (APP). We begin with a brief overview of the neuropatho...

Although today there is a wide acceptance that both genetics and environmental experiences define an animal’s behavior, at one time it was thought that perhaps environmental experience alone determined an animal’s behavior. Some of the first definitive work, published by Tryon in the 1940's, supported the genetic basis of behavior. Tryon studied rats and their ability to complete a maze. He gro...