نتایج جستجو برای: t bet

تعداد نتایج: 709950  

Journal: :Journal of immunology 2009
Sara L Colpitts Nicole M Dalton Phillip Scott

Infection with the intracellular protozoan parasite Leishmania major induces a state of concomitant immunity wherein secondary immunity is dependent upon the persistence of the original pathogen. Our laboratory has described two populations of Leishmania-induced CD4(+) T cells that contribute to immunity: CD62L(high) central memory T (T(CM)) cells and CD62L(low) effector T cells. To determine w...

Journal: :Acta microbiologica et immunologica Hungarica 2015
Soha Sadeghi Mohammad Hossein Sanati Morteza Taghizadeh Parvine Mansouri Zohreh Jadali

Alopecia areata represents an autoimmune pathological process driven primarily by cellular aberrations contained within the immune system, which activates various humoral and cellular elements of the immune response. The aim of this study was to determine the mRNA expression levels of T-bet and GATA-3 as potential inducers of T helper (Th)1 and Th2 differentiation, respectively, as well as Th1(...

2014
Jibran A Wali Helen E Thomas Andrew PR Sutherland

Obesity is a major predisposing factor for the development of type 2 diabetes (T2D) and is an escalating public health issue around the world. The transition from obesity to T2D is preceded by the induction of a state of insulin resistance, which occurs in response to genetic factors and environmental influences, such as diet. Recent advances have implicated inflammatory immune cells and cytoki...

2013
Michael R. Betts George Makedonas E. John Wherry Jordan S. Orange Laura M. McLane Pinaki P. Banerjee Gabriela L. Cosma

2008
Shaojing Chang Patrick L. Collins Thomas M. Aune

Journal: :Gut 2002
B Weigmann M F Neurath

T cells play an essential role in regulating mucosal immune responses in the gastrointestinal tract. Recent observations on T helper cell differentiation and activation by regulatory transcription factors-especially T-bet-in chronic inflammatory diseases have provided new perspectives for understanding mucosal immunity. Here we summarise recent advances in the field of transcription factors and...

2017
Michelle L T Nguyen Dimitre R Simeonov Alexander Marson

1 Department of Microbiology and Immunology, University of California, San Francisco, California, United States of America, 2 Diabetes Center, University of California, San Francisco, California, United States of America, 3 Innovative Genomics Institute, University of California, Berkeley, California, United States of America, 4 Biomedical Sciences Graduate Program, University of California, Sa...

2014
Xue Li Qiquan Sun Mingchao Zhang Kenan Xie Jinsong Chen Zhihong Liu

Antibody-mediated rejection (ABMR) remains one of the major causes of graft loss after renal transplantation. It is dominated by endothelial damage in microcirculation. Clarifying the mechanism of microcirculating damage is obviously a key step to understand the pathogenesis of ABMR. Here we characterized capillary variation in ABMR and its possible mechanisms. Compared with T cell-mediated rej...

Journal: :Journal of immunology 2003
Mark S Sundrud Stacy M Grill Donghui Ni Kinya Nagata Sefik S Alkan Arun Subramaniam Derya Unutmaz

Activation of naive T cells through the TCR and cytokine signals directs their differentiation into effector or memory subsets with different cytokine profiles. Here, we tested the flexibility of human Th1 or Th2 differentiation by forced expression of transcription factors T-bet and GATA-3. Ectopic expression of T-bet and GATA-3 in freshly isolated human T(N) cells resulted in their differenti...

Journal: :Journal of investigational allergology & clinical immunology 2010
E Streck R A Jörres R M Huber A Bergner

BACKGROUND Tobacco smoke is a key risk factor for chronic obstructive pulmonary disease, but it may also alter the pathophysiology of asthma. In the present study, we analyzed whether tobacco smoke has acute or chronic effects on bronchial tone and whether it alters bronchial reactivity in vitro. METHODS Airways in murine lung slices were digitally recorded and the change in cross-sectional a...

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