We report a case of a 19-year-old woman with a primary pericardial synovial sarcoma that extended from the right ventricular free wall to the posterior aspect of the left anterior thoracic wall. Synovial sarcoma was diagnosed by the detection of the chimeric transcript SYT-SSX using reverse transcriptase-polymerase chain reaction (RT-PCR). This transcript is generated by reciprocal translocatio...

Primary pulmonary synovial sarcoma is an extremely rare tumor with an unknown cause. The diagnosis is established after other primary lung malignancies or metastatic extrathoracic sarcoma have been excluded. We report the case of a 69-year-old man who presented with a well-defined mass in the right upper lobe on a chest X-ray. A video-assisted thoracoscopic surgery (VATS) right upper lobectomy ...

症例は45歳，男性．黒色便で近医を受診し，上部消化管内視鏡検査で十二指腸腫瘍を認めた．生検結果からは，SYT遺伝子の転座は認めないが，免疫染色や組織像から十二指腸滑膜肉腫と診断され，亜全胃温存膵頭十二指腸切除術を施行した．しかし，術後の切除検体からもSYT遺伝子転座は認めず，滑膜肉腫は否定された．EWSR1の転座は認めたが，融合遺伝子までは確定できなかった．組織像からは，round cell sarcoma with EWSR1-non-ETS fusionsという疾患概念に当てはまる可能性を指摘されたが，最終的には分類不能の紡錘細胞腫瘍との診断に至った．Round fusionsという疾患概念は2020年に新たにできた分類であり，本邦ではこの分類にかかわる報告はない．貴重な病理結果である十二指腸紡錘細胞腫瘍を経験したので報告する．

Primary synovial sarcoma of the thyroid is an extremely rare condition which has only been reported twice in the literature. We herein report a case of highly aggressive and rapidly lethal primary synovial sarcoma of the thyroid. A 72-year-old woman presented with extensive local invasion, rapid progression, and early distant metastasis secondary to primary thyroid synovial sarcoma. The tumor e...

The Standard Young Tableaux are used to label the basis vectors of the standard or Young Yamanouchi basis of the symmetric group. There is a one to one correspondence between the eigen values of the Complete Set of Commuting Operators-I (CSCO-I) of Symmetric group of degree n (Sn) and the Standard Young Tableaux(SYT). In this paper, a new graphical method to index and retrieve the standard Youn...

The incidence of malignancy occurring in pregnancy is approximately 0.7–0.1 % [1]. Sarcomas occurring during pregnancy are even rarer, and kidney is an unusual site for a synovial sarcoma (SS). The histogenesis of this tumor is unknown and is usually characterized by the specific translocation t(X; 18) (p 11.2; q 11) resulting in fusion of SYT gene on chromosome 18 with SSX gene on chromososme ...

Synovial cell sarcoma (SCS) of the kidney is a rare tumor entity with a poor prognosis. Morphologic and immunohistochemical characteristics may overlap with other more common neoplasms of the kidney. Therefore, the diagnosis of primary renal SCS not only requires the exclusion of similar tumor types, but also a confirmation of SYT-SSX gene fusion using molecular techniques. The treatment compri...

We investigated the color vision pattern in Cebus apella monkeys by means of electroretinogram measurements (ERG) and genetic analysis. Based on ERG we could discriminate among three types of dichromatic males. Among females, this classification is more complex and requires additional genetic analysis. We found five among 10 possible different phenotypes, two trichromats and three dichromats. W...

We present a 51 year old female patient with a pelvic desmoplastic small round cell tumor with an unusual immunohistochemical profile, including absence of significant cytokeratin expression, complete negativity for desmin and widespread loss of nuclear INI-1 expression (>90% of tumor cells). The neoplastic cells were positive for epithelial membrane antigen (EMA), vimentin, and WT-1 (antibody ...

The lasting effects of neuronal activity on brain development involve calcium-dependent gene expression. Using a strategy called transactivator trap, we cloned a calcium-responsive transactivator called CREST (for calcium-responsive transactivator). CREST is a SYT-related nuclear protein that interacts with adenosine 3',5'-monophosphate (cAMP) response element-binding protein (CREB)-binding pro...