The Abl tyrosine kinase inhibitor STI-571 is effective therapy for stable phase chronic myeloid leukemia (CML) patients, but the majority of CML blast-crisis patients that respond to STI-571 relapse because of reactivation of Bcr-Abl signaling. Mutations of Thr-315 in the Abl kinase domain to Ile (T315I) were previously described in STI-571-resistant patients and likely cause resistance from st...

INTRODUCTION The emergence of drug resistance among bacterial, viral and protozoan sexually transmitted infections (STI) in recent years threatens to undermine global STI control programmes. While this review will focus on microbiological resistance determinants for two important bacterial STI pathogens, namely Neisseria gonorrhoeae and Treponema pallidum, it is important to appreciate that a n...

This paper describes a conceptual framework for understanding the role of Science, Technology and Innovation (STI) in the evolving sustainable development challenge. It develops the key concepts behind STI and draws linkages between STI and the sustainable development goals, identifying some of the key challenges in strengthening STI capacities in ESCAP Member States. Lastly it sets out a pathw...

OBJECTIVES To 1) create a space where men who have sex with men (MSM) feel comfortable accessing sexually transmitted infection/human immunodeficiency virus (STI/HIV) testing, and 2) reduce STI/HIV incidence. PARTICIPANTS Gay men in Ottawa and its surrounding regions. SETTING A preponderance of diagnoses of sexually transmitted infections and HIV continue to occur among MSM. Meanwhile, othe...

To determine uptake of home sampling kit (HSK) for STI/HIV compared to clinic-based testing, whether the availability of HSK would increase STI testing rates amongst HIV infected MSM, and those attending a community-based HIV testing clinic compared to historical control. Prospective observational study in three facilities providing STI/HIV testing services in Brighton, UK was conducted. Adult ...

BACKGROUND Although number of sexually transmitted infections (STIs) reported in STI surveillance increased rapidly for women in Japan during the 1990s, the sexual behavior of women potentially at risk of STI infection remains unknown. METHODS In order to determine the demographic and behavioral characteristics of non-sex worker (SW) females attending STI clinics, female attendees (n = 145), ...

Cette synthèse examine les effets que la crise du COVID-19 pourrait avoir sur l’avenir de science, technologie et l’innovation (STI) politiques y afférentes. Les disparates recherche le développement (R&D) dans différents secteurs, l’accélération l’adoption des outils numériques techniques connexes, l’évolution degré d’ouverture, l’inclusivité l’agilité écosystèmes d’innovation sont autant ...

A new electronic surveillance system for sexually transmitted infections (STIs) was introduced in England in 2009. The genitourinary medicine clinic activity dataset (GUMCAD) is a mandatory, disaggregated, pseudo-anonymised data return submitted by all STI clinics across England. The dataset includes information on all STI diagnoses made and services provided alongside demographic characteristi...

The rates of sexually transmitted infections (STI) including chlamydia, gonorrhea, and syphilis, are increasing across the United States, including in Rhode Island (RI). These STIs affect many otherwise healthy adolescents and young adults, and represent a significant source of morbidity. The Centers for Disease Control and Prevention encourages states to develop strategies for addressing incre...