BACKGROUND Arteriovenous (AV) fistulae is an extremely rare disease of vascular malformation that involves fistulae formation between the systemic and pulmonary AV systems. CASE REPRESENTATION This case report describes a rare systemic-pulmonary AV fistulae of congenital origin, accompanied by pulmonary hypertension, as determined by aortic angiography and echocardiography. CONCLUSION Chara...

Pulmonary arterial hypertension (PAH) in systemic sclerosis (SSc) is a complex clinical situation resulting from restricted flow through the pulmonary arterial circulation ending in increased pulmonary vascular resistance and right heart failure. PAH is a common and life-threatening complication in connective tissue diseases, specifically in SSc if not treated rapidly and adequately. Based on t...

Heart transplant recipients develop systemic hypertension (SH), which is generally difficult to clinically control, requiring the use of several antihypertensive drugs. The pathophysiology involves the action of cyclosporine through the following mechanisms: alterations in the renin-angiotensin-aldosterone and sympathetic system, in prostaglandin and thromboxane A2 levels, in plasmatic endothel...

A case of systemic mastocytosis is described in which the finding on initial presentation was hepatosplenomegaly. No dermatological abnormality was present, and the bone marrow histology originally caused some confusion with primary myelofibrosis. The clinical course and the importance of distinguishing between these two diseases is discussed. The dermatological manifestation of systemic mastoc...

almost incredulous envy in countries where such addiction is still a serious problem. These measures have been wholly salutary, but future legislation concerning the safety of drugs is bound to be more difficult, because no drug is ever entirely safe and its safety must be related to the purpose for which it is to be used. For example, a high degree of toxicity might be tolerated if a drug cure...

t rue saccular aneurysm is exceptional in coarctation of aorta in children. a 6-year-old girl with headache and systemic arterial hypertension referred to our center for cardiovascular evaluation. physical examination revealed high blood pressure and weak lower extremity pulses. two-dimensional and doppler echocardiography and angiography demonstrated a saccular aneurysm of the descending aorta...

We report a case of systemic mastocytosis (SM) presenting as ascites and portal hypertension. The haematological picture at presentation was suggestive of chronic myelomonocytic leukaemia. Initial difficulties in making a diagnosis of SM were encountered as the cutaneous signs were atypical. The correct diagnosis was established only after tissue sections were appropriately stained for mast cel...

Objective: Assessment of left atrium (LA) deformation by 2-Dimensional Speckle Strain Imaging (2DSI) has been recently proposed as an alternative method of exploring LA function. The purpose of this study was to assess the relationship of LA function, particularly reservoir function, with LA structural remodeling related to left ventricular hypertrophy (LVH) in patients with hypertension (HTN) ...

The circulatory responses to sustained handgrip at 30 per cent of a maximum voluntary contraction of the forearm muscles (MVC) were examined in untreated hypertensive patients. Arterial pressure increased in all patients, often attaining very high levels. Two main patterns of circulatory response were observed. In group i (8 patients) there was an increase in cardiac index and heart rate, with ...

A quantitative study of arteriolar structure has been undertaken in 23 individuals with chronic hypertension and 18 normotensive controls. In the hypertensive individuals, some arterioles were found to have an increased, and others a subnormal, mass of medial smooth muscle. Both abnormalities often bear a definite relation to arteriolar sclerotic lesions, those arterioles proximal to sclerotic ...