نتایج جستجو برای: systemic cancers
تعداد نتایج: 264031 فیلتر نتایج به سال:
Lymph-node metastasis (LNM) predict high recurrence rates in breast cancer patients. Systemic treatment aims to eliminate (micro)metastatic cells. However decisions regarding systemic treatment depend largely on clinical and molecular characteristics of primary tumours. It remains, however, unclear to what extent metastases resemble the cognate primary breast tumours, especially on a genomic le...
Abstract Introduction DIT allows for targeted delivery to a cancer. This could deescalate treatments through reduced use of systemic chemotherapy, radiotherapy dosage, and avoidance major surgery. Palliative cancers can benefit similar means maintain quality life avoid permanent interventions (such as stomas). There is no mainstream DIT. Therefore, the aim this review was assess role in all can...
Introduction: Lung cancer is the number-one cause of death due to neoplasms worldwide. The 5-year overall survival rate only 22%. In advanced stages, therapeutic options are limited chemotherapy, radiotherapy, molecularly targeted therapy and immunotherapy. Phytocannabinoids, components Cannabis sativa, their synthetic derivatives endogenous cannabinoids have demonstrated anticancer activity in...
UNLABELLED In a national prospective registry, we previously studied the impact of (18)F-sodium fluoride PET (NaF PET) on the intended management of cancer patients with osseous metastases. The clinical impact of NaF PET for monitoring the response to systemic therapies in such patients is unknown. The objective of this study was to assess the impact of NaF PET results obtained for treatment mo...
background and aims: the aim of this study was the modeling of the incidence rates of colorectal, breast and prostate cancers using a shared component model in order to explore the spatial pattern of their shared risk factors (i.e., obesity and low physical activity) affecting on cancer incidence, and also to estimate the relative weight of these shared components. methods: in this study, the ...
BACKGROUND Patients with some autoimmune diseases (AIDs) are at increased risk of cancer, possibly a result of an underlying dysregulation of the immune system, medication, treatment or, probably, surveillance bias. Data on cancer mortality and survival in patients previously diagnosed with AIDs would provide novel information on these comorbidities and their clinical implications. PATIENTS A...
INTRODUCTION The aim of this study was to assess cancer incidence in childhood-onset systemic lupus erythematosus (SLE). METHODS We ascertained cancers within SLE registries at 10 pediatric centers. Subjects were linked to cancer registries for the observational interval, spanning 1974 to 2009. The ratio of observed to expected cancers represents the standardized incidence ratio (SIR) or rela...
BACKGROUND Dysregulation of the immune function in autoimmune diseases could potentially lead to cancer development and there is definite evidence linking some autoimmune mechanisms with cancer. We analyzed systematically the occurrence of histology-specific digestive tract cancers in patients diagnosed with 33 different autoimmune diseases in order to address the question of shared susceptibil...
Inhibitors of the poly(adenosine triphosphate-ribose) polymerase (PARP)-1 enzyme induce synthetic lethality in cancers with ineffective DNA (DNA) repair or homologous repair deficiency, and have shown promising clinical activity in cancers deficient in DNA repair due to germ-line mutation in BRCA1 and BRCA2. The majority of breast cancers arising in carriers of BRCA1 germ-line mutations, as wel...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید