this evaluation was undertaken to analyse the overall merit of studies for publication in medical journals. peer review, in which peer experts evaluate the value of a manuscript submitted to a professional journal, is regarded as a crucial step in publication. it helps to ensure that published articles describe experiments that focus on important issues and that the research is well designed an...

Recognition of the need for good research synthesis dates back almost half a century (c.f .WRIGHT MILLS, 1959), although it is far more recently that specific methods of synthesis have been developed. NOBLIT and HARE (1988) argue that such methods have emerged because of the failings, in the eyes of both positivists and interpretivists, of traditional literature reviews which, while giving an o...

Background: Understanding the differences in genetics of malignancies is crucial for therapeutic decisions. This systematic review was conducted to evaluate the current evidence on genetics of bone tumors in the context of pediatric cancer. Material and Methods: We performed a systematic review of the literature published on genetics of pediatrics bone tumors, using PubMed, Google scholar,...

BACKGROUND Soil-transmitted helminths (STH) have acute and chronic manifestations, and can result in lifetime morbidity. Disease burden is difficult to quantify, yet quantitative evidence is required to justify large-scale deworming programmes. A recent Cochrane systematic review, which influences Global Burden of Disease (GBD) estimates for STH, has again called into question the evidence for ...

BACKGROUND Animal research suggests that neural reward activation may be systematically modulated by sleep and circadian function. Whether humans also exhibit sleep and circadian modulation of neural reward pathways is unclear. This area is in need of further research, as it has implications for the involvement of sleep and circadian function in reward-related disorders. The aim of this paper i...

This section will be led in order to provide the clinician with support for comprehension and critical analysis of scientific articles, with elucidation of the main types of scientific studies, specific methodology and statistical analysis for clinical practice based in scientific evidence. The objective is to approximate clinician and science, easing the comprehension of the intricate scientif...

A literature review provides a basis for consolidating research findings within a specific area into a cohesive document that gives a clear indication of current progress, limitations and future directions of the research stream. It allows practitioners and researchers alike to keep abreast of the latest research findings (e.g., on evidence-based therapeutic interventions). The aim of this pape...

A systematic review of the neuroanatomical literature was performed to determine the neuropharmacological aspects most relevant to the study of memory processes. Articles were retrieved using the search terms "biology of memory", "memory and aging", "memory impairment", "elderly and memory," and their equivalents in Portuguese. Of the studies surveyed, five studies dealt with epidemiological an...

results the search criteria yielded 16 manuscripts on percutaneous adhesiolysis assessing post-surgery syndrome. of these, only 4 randomized trials met inclusion criteria for methodological quality assessment, 3 of them were of high quality; and the fourth manuscript was of low quality. based on these 3 randomized controlled trials, 2 of them with one-day procedure and one with a 3-day procedur...