Four new 1,5-benzothiazepines were synthesized by reaction of o-aminothiophenol with curcumin and curcuminoid β-diketones, in methanol acetic acid. The mechanism involves a Michael addition on the CC double bond affording benzothiazepine two pendant groups, an aryl group adjacent to sulfur atom 1-phenylethanone NH seven membered ring. 1D 2D multinuclear NMR (1H, 13C, 15N, 119F) solution 13C 15N...

Cross-polarization (CP) magic angle spinning (MAS) 13C NMR spectroscopy has become a routine tool in pharmacy, employed to identify and characterize drugs in the solid phase. 13C CPMAS NMR spectra were recorded for solid hydrocortisone 21-hemisuccinate and suxamethonium chloride. White crystalline substances, such as these two drugs, can be easily distinguished; and solid-state 13NMR spectra of...

This study aimed to evaluate changes in glucose metabolism at the early stage and onset of diabetes in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Specifically, after the oral administration of [1, 2, 3-13C]glucose, the levels of exhaled 13CO2, which most likely originated from pyruvate decarboxylation and tricarboxylic acid, were measured. Eight OLETF rats and eight control rats (Long-Evan...

Assignment of the fifteen carbons of terrecyclic acid A, C15H20O3, a new sesquiterpene antibiotic, in the 13C NMR spectrum was performed by 13C-[1H] selective proton decoupling experiments, comparison with spectra of its derivatives and chemical shifts.

High-resolution 13C nuclear magnetic resonance spectra of suspensions of Escherichia coli cells have been obtained at 90.5 MHz by using the Fourier transform mode. Anaerobic cells incubated with [I-13C]glucose show a time course of glycolysis in which the alpha and beta glucose anomers disappear at different rates, lactate, succinate, acetate, alanine, and valine accumulate as end products of g...

The recent discovery of leptin receptors in peripheral tissue raises questions about which of leptin's biological actions arise from direct effects of the hormone on extraneural tissues and what intracellular mechanisms are responsible for leptin's effects on carbohydrate and lipid metabolism. The present study is focused on the action of leptin on hepatic metabolism. Nondestructive 13C NMR met...

High-resolution solid state 13C, 23Na and 31P NM R data have been obtained for the acid form and for several salts o f the phosphonic acids: ethane-1 ,2 -diphosphonic acid, ethane-l-hydroxy1.1-diphosphonic acid (H E D P ), and 3-am ino-l-hydroxypropane-l,l-diphosphonic acid. The data provide evidence by which sample purity and crystallinity may be examined and from which the size of the asymmet...