context despite advancements in the science of surgery, minimizing bleeding from parenchymal tissue of the liver continues to be one of the challenges surgeons are facing to protect patients’ lives. however, the number of surgeries needing incisions in the liver tissue, e.g. metastatectomy, is constantly increasing. conclusions the excessive blood loss and the long time needed to control the bl...

A microwave-assisted synthesis of cisplatin, cis-[Pt(NH3)2Cl2], has been developed and optimized on both a 0.2 and 0.05 millimolar scale. The optimized synthetic procedure was modeled after the Lebedinskii-Golovnya method and is suitable for incorporating the radionuclide, (195m)Pt, into cisplatin for biological studies. Highest yields (47%) and purity are obtained using a K2PtCl4 : NH4OAc : KC...

conclusion metallic stent placement is a safe and effective procedure for salvage of native hemodialysis fistula after unsuccessful balloon angioplasty. results twenty-one stents were applied. the anatomical and clinical success rate was 100%. seventeen additional interventions were done for 11 (55%) patients due to stent thrombosis or stenosis during follow-up. our 1- and 2-year secondary pate...

The total synthesis of natural products and biologically active compounds, such as pharmaceuticals and agrochemicals, has reached an extraordinary level of sophistication. We are, however, still far away from the 'ideal synthesis' and the state of the art is still frequently hampered by lengthy protecting-group strategies and costly purification procedures derived from the step-by-step protocol...

The influence of GABA on the synthesis of N-acetylserotonin, melatonin, O-acetyl-5-hydroxytryptophol and O-acetyl-5-methoxytryptophol has been investigated using different experimental procedures. It was demonstrated that when GABA and an acetyl donor were added to the incubation medium together, a significant increase in synthesis of the N-acetylated products occurred during the night. Moreove...

A microwave-assisted synthesis of cisplatin, cis-[Pt(NH3)2Cl2], has been developed and optimized on both a 0.2 and 0.05 millimolar scale. The optimized synthetic procedure was modeled after the Lebedinskii-Golovnya method and is suitable for incorporating the radionuclide, Pt, into cisplatin for biological studies. Highest yields (47 %) and purity are obtained using a K2PtCl4:NH4OAc:KCl molar r...

BACKGROUND Measurement of mitochondrial ATP synthesis is a critical way to compare cellular energetic performance. However, fractionation of mitochondria requires large amounts of cells, lengthy purification procedures, and an extreme caution to avoid damaging intact mitochondria, making it the highest barrier to high-throughput studies of mitochondrial function. To evaluate 45 genes involved i...

Background Fast implementation of positron emission tomography (PET) into clinical and preclinical studies highly demands automated synthesis for the preparation of PET radiopharmaceuticals in a safe and reproducible manner. The aim of this study was to develop automated synthesis methods for these six 18F-labeled radiopharmaceuticals produced on a routine basis at the University of Pennsylvani...

In this paper, a novel method for the selection of synthesis unit is proposed. The monosyllables are adopted as the basic synthesis units. A set of high-quality synthesis units is selected from a large continuous speech database based on four procedures: pitch period detection and smoothing, speech unit filtering, unit selection, and manual examination. Two cost functions are proposed for obtai...

Introduction In recent years, a new approach called “Green Chemistry” emerged in the field of organic chemistry, to prevent or minimize contamination from the laboratory bench up to industrial production. It purpose is to avoid residue formation, saving time and costs. One of the strategies proposed for the existing products involves designing alternative synthesis steps that do not use toxic s...