INTRODUCTION Rheumatoid arthritis (RA) is an autoimmune disease that is characterized by severe synovitis and cartilage destruction. Synovial cells play a major role in the pathogenesis of RA through the synthesis of various cytokines, proteases, superoxide, etc. Interleukin-8 (IL-8), one of CXC chemokines, is known to recruit neutrophils into inflammatory loci. Chemokines have been reported to...

OBJECTIVE Cytokines play an important role in the pathology of rheumatoid arthritis (RA). Macrophage migration inhibitory factor (MIF) is a cytokine with a broad spectrum of actions, including induction of monocyte tumour necrosis factor alpha (TNF-alpha). Evidence of the expression and proinflammatory activity of MIF has recently been demonstrated in RA synovium and in animal models of RA. We ...

Radiosynovectomy is a safe and repeatable treatment method of chronic synovitis with synovial overgrowth and refractory chronic or acute inflammatory joint effusion. It consist in the intraarticular administration of a radioactive isotope in the form of a colloid causing the extinguishing of active synovitis. The radiocolloid causes permanent irradiation of the synovium with beta ray electron b...

Abstract The synovium of osteoarthritis (OA) patients can be characterized by an abnormal accumulation macrophages originating from extravasated monocytes. Since targeting monocyte extravasation may represent a promising therapeutic strategy, our aim was to develop organotypic microfluidic model recapitulating this process. Synovium and cartilage were modeled hydrogel-embedded OA synovial fibro...

Rheumatoid arthritis (RA) is a systemic autoimmune disorder that manifests as chronic inflammation and joint tissue destruction. However, the etiology and pathogenesis of RA have not been fully elucidated. Here, we explored the role of the hypoxia-inducible factors (HIFs), HIF-1α (encoded by HIF1A) and HIF-2α (encoded by EPAS1). HIF-2α was markedly up-regulated in the intimal lining of RA synov...

BACKGROUND The anti-human Fas/APO-1/CD95 (Fas) mouse/human chimeric monoclonal IgM antibody ARG098 (ARG098) targets the human Fas molecule. The cytotoxic effects of ARG098 on cells isolated from RA patients, on normal cells in vitro, and on RA synovial tissue and cartilage in vivo using implanted rheumatoid tissues in an SCID mouse model (SCID-HuRAg) were investigated to examine the potential o...

Objective: To gain a better understanding of how iron accumulates in human rheumatoid synovium. Methods: The distribution of ferritin, transferrin receptor, and non-specific resistance associated macrophage proteins 1 and 2 (Nramp1 and Nramp2) in the human rheumatoid synovium was investigated by immunocytochemistry and reverse transcriptase-polymerase chain reaction (RT-PCR). Results: Both heav...

OBJECTIVE For the inflammation characteristic of rheumatoid arthritis, the relative contribution of mediators produced locally in the synovium versus those circulating systemically is unknown. Complement factor C3 is made in rheumatoid synovium and has been proposed to be a crucial driver of inflammation. The aim of this study was to test, in a mouse model of rheumatoid arthritis, whether C3 sy...

Recurrent hemarthrosis after knee arthroplasty can be disabling, requiring adequate and immediate diagnosis and treatment for recovery of symptoms and joint function. The most commonly reported cause is impingement of proliferative synovium between prosthetic components. Although various procedures for hemarthrosis have been reported after knee arthroplasty for patients who do not respond to co...

Recent years have seen enormous progress in understanding the pathogenesis of rheumatoid arthritis (RA), an autoimmunological disorder that primarily affects the joints and leads to their progressive destruction. Advances in molecular biology techniques such as the use of gene transfer and gene silencing technology, the utilization of novel animal models of destructive arthritis–particularly in...