Purpose. In the mouse model of oxygen-induced retinopathy (OIR), somatostatin-14 (SRIF) acting at the SRIF receptor subtype 2 (sst(2)) inhibits angiogenic responses to hypoxia through a downregulation of vascular endothelial growth factor. Information about where SRIF-sst(2) interactions take place is lacking, and downstream effectors mediating SRIF-sst(2) antiangiogenic actions are unknown. Me...

Locally produced growth hormone (GH) and IGF-I are key factors in the regulation of mammary gland (MG) development and may be important in breast cancer development/progression. Somatostatin (SST) and cortistatin (CORT) regulate GH/IGF-I axis at various levels, but their role in regulating GH/IGF-I in MGs remains unknown. Since obesity alters the expression of these systems in different tissues...

Steady State Tokamak (SST-1) refurbishment at the Institute for Plasma Research has been recognized and accepted as a Mission activity since Jan 2009 with an ultimate objective of producing the first plasma by the end of 2011. Under the SST-1 Mission mandate, several refurbishment activities have been initiated and pursued vigorously on various sub-systems of SST-1. Developing reliable designs ...

Recent Lagrangian analyses of surface drifters have questioned the existence of a surface current connecting the Gulf Stream (GS) to the subpolar gyre (SPG) and have cast doubt on the mechanism underlying an apparent pathway for sea-surface temperature (SST) anomalies between the two regions. Here we use modelled Lagrangian trajectories to determine the fate of surface GS water and satellite SS...

Single Step Tableaux (SST) are the basis of a calculus for modal logics that combines different features of sequent and prefixed tableaux into a simple, modular, strongly analytic, and effective calculus for a wide range of modal logics. The paper presents a number of the computational results about SST (confluence, decidability, space complexity, modularity, etc.) and compares SST with other f...

Cushing’s disease is Cushing’s syndrome caused by an adrenocorticotropic hormone-secreting pituitary adenoma and, in the absence of adequate treatment, can be fatal. Cushing’s disease represents an unmet medical need, with no approved medical therapies. Pasireotide is a novel multi-receptor-targeted somatostatin analogue with high affinity for sst 1,2,3 and sst 5 . Compared with octreotide, pas...

Somatostatin is highly expressed in mammalian brain and is involved in many brain functions such as motor activity, sleep, sensory, and cognitive processes. Five somatostatin receptors have been described: sst(1), sst(2) (A and B), sst(3), sst(4), and sst(5), all belonging to the G-protein-coupled receptor family. During the recent years, numerous studies contributed to clarify the role of soma...

The Antarctic circumpolar wave (ACW) is a nominal 4-yr climate signal in the ocean–atmosphere system in the Southern Ocean, propagating eastward at an average speed of 6–8 cm s21, composed of two waves taking approximately 8 years to circle the globe. The ACW is characterized by a persistent phase relationship between warm (cool) sea surface temperature (SST) anomalies and poleward (equatorward...

UNLABELLED A variety of radiolabeled somatostatin analogs have been developed for targeting of somatostatin receptor (sst)-positive tumors. Bicyclic somatostatin-based radiopeptides have not been studied yet. Hypothesizing that the introduction of conformational constraints may lead to receptor subtype selectivity or may help to delineate structural features determining pansomatostatin potency,...

[1] Restricted zones of recent dissolution and secondary aragonite infilling were identified in a coral core collected in 1986 from a living massive Porites colony from the central Great Barrier Reef, Australia. Secondary aragonite needles, 20 mm long, cover skeletal surfaces deposited from 1972 to late 1974 and increase bulk density by 10%. Dissolution is observed above this zone, whereas olde...