OBJECTIVE Trypophobia refers to the fear of, or aversion to, clusters of holes. We assessed clinical features of trypophobia and investigated whether it most resembled a specific phobia or obsessive-compulsive disorder. METHODS An online survey was conducted to gather information on sociodemographic variables, course and duration, severity, associated features, comorbid psychiatric diagnoses,...

We report here a patient in whom the effects of a cerebellum mass may have led to development of obsessive-compulsive disorder (OCD). A 33-year-old woman showed symptoms of OCD, including obsessive worry about infection from tainted blood and repetitive confirmation, which worsened during pregnancy. She had comprehension in regard to her illness and no evidence of cognitive dysfunction and did ...

N-acetylcysteine (NAC) is a well-known and safe mucolytic agent, also used in patients with paracetamol overdose. In addition to these effects, recent preclinical clinical studies have shown that NAC exerts beneficial effects on different psychiatric disorders. Many potential mechanisms been proposed underlie the therapeutic of NAC, including regulation several neurotransmitters, oxidative home...

Researchers postulate that both shame and guilt are emotions important to anxiety disorders. Extant data, however, indicate that guilt-proneness shares non-significant relationships with psychopathology symptoms after controlling for shame-proneness. To further investigate the relevance of shame and guilt to the anxiety disorders domain, the current study examined associations between shame- an...

objective: the fact that some antidepressants with strong effects on serotonin reuptake blockade fail to relieve obsessive-compulsive symptoms has caused growing interest in investigating noradrenergic function in obsessive-compulsive disorder (ocd) . in light of the above, we undertook a trial to investigate whether the combination of citalopram with nortriptyline is more effective in treating...

The Gilles de la Tourette syndrome (GTS) is a neurobehavioural disorder characterized by multiple motor and vocal tics. Accessory symptoms include coprophenomena, echophenomena and obsessive-compulsive behaviours. There is a significant genetic contribution to their aetiology. Simple tics may be mistaken for myoclonic epilepsy and complex tics for complex partial seizures. Like epilepsy, GTS is...

There is compelling evidence to implicate dopamine in the etiology of obsessive compulsive disorder (OCD). Administration of amphetamine (Ellinwood, 1967) phenmetrazine and L dopa produces obsessive symptoms. Furthermore, a recent study indicated in Tourette's syndrome patients, fluvoxamine worsened tics, coprolalia and OCD but the addition of pimozide improved both OCD and tics (McDougle et al...

Background& Objective: Temporal lobe epilepsy has been associatedwith psychopathology especially obsessive-compulsive (OC) traits or symptoms as one of it’s specific personality characteristics as compared to other epilepsies. This study was undertaken to assess the prevalence and type of OC symptoms in patients with complex partial seizures (CPS) and generalized seizure disorders and the assoc...

OBJECTIVE The aim of this study was to determine the childhood clinical predictors of early adult outcomes in pediatric-onset obsessive-compulsive disorder (OCD) and to assess whether dimensional subtypes of OCD and the presence of comorbid tic symptoms influence long-term outcomes. METHODS We conducted a longitudinal cohort study in which 45 of 62 eligible children with OCD were reassessed a...