Despite extensive research on the pathogenesis of polycystic ovary syndrome (PCOS), there is still disagreement on the underlying mechanisms. The rat model for experimentally induced polycystic ovaries (PCO)-produced by a single injection of estradiol valerate-has similarities with human PCOS, and both are associated with hyperactivity in the sympathetic nervous system. Nerve growth factor (NGF...

Aging is associated with structural and functional changes in the autonomic nervous system (ANS), which innervates the whole body, and its altered function may influence almost all body systems. Changes related to aging are found in autonomic nerves and ganglia, and ANS controlled functions including cardiovascular functions. Much of the current knowledge about age-related changes in sympatheti...

Keywords: chronic renal failure, sympathetic nervous It is therefore surprising that so far nephrologists have neglected the therapeutic potential of modulating system, hypertension sympathetic nervous activity in chronic renal failure. This is even more strange, since there is convincing evidence to show that in chronic renal failure sympath

The objective: was to evaluate the effectiveness of various anesthesia options for laparoscopic hysterectomy, including low-opioid (LOA) and opioid-free (OFA) by studying dynamics heart rate variability (HRV) indicators.Materials methods. 102 patients were randomly assigned 3 groups: 37 who received standard opioid (control group), 33 women LOA group, 32 OFA.Results. Laparoscopic hysterectomy i...

For almost a century it is discussed that activity in the sympathetic nervous system may be involved in the generation of pain, e.g., in causalgia and reflex sympathetic dystrophy. This assumption is based mainly upon two observations: (1) the pain is spatially correlated with signs of autonomic dysfunction, i.e., with abnormalities in blood flow and sweating, as well as with trophic changes, a...

Results from animal experimentation suggest a 2-way interaction between leptin and the sympathetic nervous system, with leptin causing sympathetic activation and conversely, with the sympathetic system exercising regulatory feedback inhibition over leptin release. We have now tested this hypothesis in humans. In the absence of results from leptin infusions, to test for sympathetic stimulation o...

One of the major pathophysiological features of primary hypertension is an inappropriate activation of the sympathetic nervous system, which is mediated by excessive synthesis and secretion of catecholamine into the blood. Tyrosine hydroxylase (TH), a rate-limiting enzyme in the synthesis of catecholamine, has been highlighted because genetic variations of TH could alter the activity of the sym...