Neurogenesis and gliogenesis continue in discrete regions of the adult mammalian brain. A fundamental question remains whether cell genesis occurs from distinct lineage-restricted progenitors or from self-renewing and multipotent neural stem cells in the adult brain. Here, we developed a genetic marking strategy for lineage tracing of individual, quiescent, and nestin-expressing radial glia-lik...

Organogenesis relies on the spatiotemporal balancing of differentiation and proliferation driven by an expanding pool of progenitor cells. In the mouse pancreas, lineage tracing at the population level has shown that the expanding pancreas progenitors can initially give rise to all endocrine, ductal, and acinar cells but become bipotent by embryonic day 13.5, giving rise to endocrine cells and ...

We present an original apparatus combining an acoustic levitator and a pressure-compatible process chamber. To characterize in situ the chemical and physical modifications of a levitated, single particle while heated to well-defined temperatures using a carbon dioxide laser, the chamber is interfaced to a Raman spectroscopic probe. As a proof-of-concept study, by gradually increasing the heatin...

Laguerre–Gaussian beams are structured light with a donut-shaped symmetric intensity profile and helical phase profile. The beam is defined by quantized parameter known as the mode number which extends to infinity. availability of unbounded modes makes these promising candidate for next-generation optical computing, communication technologies. can be made asymmetric through certain techniques t...

We present symmetric and asymmetric similarity measures for labeled directed rooted graphs that are inspired by the simulation and bisimulation relations on labeled transition systems. Computation of the similarity measures has close connections to discounted Markov decision processes in the asymmetric case and to perfect-information stochastic games in the symmetric case. For the symmetric cas...

BACKGROUND Identifying the DNA binding sites for transcription factors is a key task in modeling the gene regulatory network of a cell. Predicting DNA binding sites computationally suffers from high false positives and false negatives due to various contributing factors, including the inaccurate models for transcription factor specificity. One source of inaccuracy in the specificity models is t...

Projecting bilinear pairings have frequently been used for designing cryptosystems since they were first derived from composite order bilinear groups. There have been only a few studies on the (im)possibility of projecting bilinear pairings. Groth and Sahai showed that projecting bilinear pairings can be achieved in the prime-order group setting. They constructed both projecting asymmetric bili...

The laser induced fluoresence excitation spectrum for the à A1 ↔ X̃ 2E transition of the methoxy radical has been reinvestigated. An extensive set of vibrational levels has been assigned with the aid of increased vibrational and rotational cooling. Many of these vibrational assignments are confirmed by rotational analysis of bands involving both the symmetric and asymmetric fundamentals of the Ã...