Recently, a new surrogate method, the Small–Shuffle (SS) surrogate method, has been proposed to investigate whether there is some kind of dynamics in irregular fluctuations, even if they are modulated by long term trends or periodicities. This situation is theoretically incompatible with the assumption underlying previously proposed surrogate methods. We apply the SS surrogate method to a varie...

In this supplementary section, we describe the Iterated Amplitude Adjusted Fourier Transform (IAAFT) method. This method was adapted for the construction of surrogate glial activities (see ‘Surrogate method’ section in the main text). The IAAFT is known for its applications in physics [1, 2] as well as econometrics [3, 4]. Described below is the procedure for a single loop of IAAFT. Let {G(t)}t...

Background Native T1 mapping is becoming established to help diagnose and monitor myocardial disease. The reproducibility of T1 mapping has not been well characterized, despite the important implications both for interpreting serial clinical studies, and for sample size calculation for surrogate endpoint in clinical trials. The SCMR consensus statement recommends measuring T1 in 2 imaging views...

a major constraint to the application of any form of knowledge and principles is the awareness, understanding and acceptance of the knowledge and principles. systems thinking (st) is a way of understanding and thinking about the nature of  health systems and how to make and implement decisions within health systems to maximize desired and minimize undesired effects. a major constraint to applyi...

BACKGROUND There is common belief among some medical researchers that if a potential surrogate endpoint is highly correlated with a true endpoint, then a positive (or negative) difference in potential surrogate endpoints between randomization groups would imply a positive (or negative) difference in unobserved true endpoints between randomization groups. We investigate this belief when the pote...

Scatter Search and its generalized form Path Relinking, are evolutionary methods that have been successfully applied to hard optimization problems. Unlike genetic algorithms, they operate on a small set of solutions and employ diversification strategies of the form proposed in Tabu Search, which give precedence to strategic learning based on adaptive memory, with limited recourse to randomizati...

Multi-constraint quality-of-service routing will become increasingly important as the Internet evolves to support real-time services. It is well known however, that optimum multi-constraint QoS routing is computationally complex, and for this reason various heuristics have been proposed for routing in practical situations. Among these methods, those that use a single mixed metric are the mo...

Introduction. Legionella is frequently detected in Dental Unit Waterlines (DUWLs). Although such a high occurrence is not necessarily associated with high risk for Legionnaire’s disease among patients and staff, it is prudent to monitor DUWLs for Legionella periodically. Since this procedure is long and expensive, surrogate markers are frequently

It is commonly believed that the correlations between stock returns increase in high volatility periods. We investigate how much of these correlations can be explained using conditional averages within a simple onefactor description. Using surrogate data with the true market return as the dominant factor, we show that most of these correlations can be accounted for. However, more subtle effects...

INTRODUCTION Falling is a frequent cause of serious injury in the older adult population and trips are a dominant cause of falls. Although there are few laboratory protocols that induce actual trips, there are many studies that utilize surrogate tasks. Performance of surrogate tasks require similar biomechanical characteristic stepping responses, but unlike a trip, these tasks do not involve an...