There has been great recent interest in the medical and statistical literature in the assessment and validation of surrogate endpoints as proxies for clinical endpoints in medical studies. More recently, authors have focused on using metaanalytical methods for quantification of surrogacy. In this article, we extend existing procedures for analysis based on the accelerated failure time model to ...

SUMMARY The widespread use of high-resolution, real time ultrasound has enabled physicians to identify a variety of fetal anatomy abnormalities. About 15-25% of fetal diseases can be diagnosed and even treated antenataly. This is a report of a case with fetal ovarian Cyst which has been confirmed with ultrasonography both antcnataly and postantaly, and caused intestinal obstruction in neonate...

The gestational surrogate--and her economic and educational vulnerability in particular--is the focus of many of the most persistent worries about paid surrogacy. Those who employ her, and those who broker and organize her services, usually have an advantage over her in resources and information. That asymmetry exposes her to the possibility of exploitation and abuse. Accordingly, some argue fo...

Background: The Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is the most common cause of uterine aplasia, with a worldwide frequency 1 in 4500 females. Although abundant literature present regarding different available methods for creating neovagina MRKH syndrome, attention dedicated to these women’s reproductive potential remains insufficient. Methods: Online searches were carried out PubMed...

Introduction and Aim: Infertility is a social stigma in India. affects 10% of the population Surrogacy an advanced form assisted reproductive technique (ART) wherein one woman bears baby for another woman. alternative infertile parents whom it difficult to have due medical reasons. The aim was assess knowledge, attitude, perception about ethical issues involved surrogacy among urban working wom...

BACKGROUND Ovulatory dysfunction is a group of disorders with variable clinical presentations occasionally having serious long-term adverse effects. It accounts for 30% of female fertility problems. Evidence suggests an association between an individual's weight and disorders of ovulation. The objective of our study was to describe the clinical and hormonal profile of subfertile women with ovul...

BACKGROUND Diminished ovarian reserve (DOR) is a heterogeneous disorder causing infertility, characterized by a decreased number of oocytes, the genetic cause of which is still unknown. METHODS AND RESULTS We describe a family with a new unbalanced X;18 translocation der(X) associated with either fully attenuated or DOR phenotype in the same family. Cytogenetics and array comparative genomic ...

<p><em>Sewa rahim (surrogate mother) merupakan sebuah inovasi di bidang kesehatan dan teknologi yang memungkinkan pembuahan terjadi luar tubuh ditanamkan lagi dalam perempuan lain. Penemuan ini menambah daftar bagi pasangan suami isteri tidak bisa menghasilkan keturunan. Prakt</em><em>ik sewa sudah mulai banyak lakukan oleh berbagai negara Indonesia, meskipun kasus Indon...