Background: INSURE (Intubation, Surfactant administration, and Extubation) therapy is controversial in managing respiratory distress syndrome (RDS) late preterm newborns. This study aims to determine whether the use of infants with RDS associated improved outcomes compared similar managed CPAP alone. Methods: A retrospective cohort two different neonatal care units treatments Bucaramanga, Colom...

A significant ratio of late preterm infants receives surfactant therapy (ST) for respiratory distress syndrome (RDS) and for other neonatal lung diseases characterized by surfactant inactivation or dysfunction. We aimed to investigate the clinical and therapeutic characteristics and outcomes of late preterm infants who received ST in the last 10 years in our neonatal intensive care unit. During...

BACKGROUND Surfactant therapy is effective in improving the outcome of very preterm infants. Trials have studied a wide variety of surfactant preparations used either to prevent or treat respiratory distress syndrome (RDS). In animal models, prophylactic surfactant leads to more homogeneous distribution and less evidence of lung damage. However, administration requires intubation and treatment ...

Liquid can be instilled into the pulmonary airways during medical procedures such as surfactant replacement therapy, partial liquid ventilation, and pulmonary drug delivery. For all cases, understanding the dynamics of liquid distribution in the lung will increase the efficacy of treatment. A recently developed imaging technique for the study of real-time liquid transport dynamics in the pulmon...

BACKGROUND Alveolar Type II cell transplantation has been proposed as a cell therapy for the treatment of idiopathic pulmonary fibrosis. Its long-term benefits include repair of lung fibrosis, but its success partly depends on the restoration of lung homeostasis. Our aim was to evaluate surfactant protein restoration after alveolar Type II cell transplantation in an experimental model of bleomy...

Bronchopulmonary dysplasia (BPD) remains the most common pulmonary cause of mortality and long-term morbidity in preterm infants. The two major pharmacologic advances in perinatal medicine have been antenatal corticosteroids to decrease the incidence of respiratory distress syndrome (RDS) (1) and surfactant to treat RDS (2). However, both therapies increase the survival of the most fragile extr...

Idiopathic pulmonary fibrosis (IPF) has a high mortality rate, and current therapies are only marginally effective. A serum biomarker that predicts clinical outcome would be useful to stage disease, indicate prognosis and the need for aggressive therapy, and help stratify patients for clinical trials. The goals of this study were to determine whether serum levels of surfactant protein-A (SP-A) ...

This paper considers the propagation of a liquid plug, forced by a driving pressure DP, within a rigid tube. The tube is already lined with a liquid precursor film of thickness h̄2 . Both the plug and the precursor film, as well as the interface, contain small amounts of surfactant whose concentrations are assumed to be near equilibrium. Since the motions are slow, we seek asymptotic solutions f...

BACKGROUND Clearance of apoptotic neutrophils in the lung is an essential process to limit inflammation, since they could become a pro-inflammatory stimulus themselves. The clearance is partially mediated by alveolar macrophages, which phagocytose these apoptotic cells. The phagocytosis of apoptotic immune cells by monocytes in vitro has been shown to be augmented by several constituents of pul...