In this work, we explore the sensing applications of Surface Plasmon Resonance (SPR) enhanced transmission of light through 1-D metal gratings on commonly available compact discs (CDs). We show that SPR on CDs (CD-SPR) can be used to build a simple and compact angular displacement measurement system with submicro-radian resolution. In addition we show that by controlling the azimuthal angle of ...

Surface plasmon resonance (SPR) is an optical sensing technique that is capable of performing real-time, label-free and high-sensitivity monitoring of molecular interactions. SPR biosensors can be divided according to their operating principles into angle-, wavelength-, intensity- and phase-interrogated devices. With their complex optical configurations, phase-interrogated SPR sensors generally...

A surface plasmon resonance (SPR) imaging biosensor based on silver substrates was investigated to demonstrate that silver could be used as a substrate material for sensitive detection of biomolecular interactions, despite its poor chemical stability. The calculation results showed that oxidation of silver film may lead to a decrease in the sensitivity due to a variation in SPR characteristics ...

Localized surface plasmon resonance (SPR) biosensors with metallic nanowires regularly patterned on a gold film are considered for sensitivity nhancement. The theoretical investigation was conducted using rigorous coupled wave analysis in terms of various design metrics, such as the esonance angle shift, the SPR curve angular width, and the minimum reflectance at resonance. The results show tha...

A commercial system for surface plasmon resonance (SPR) possessing a batch-type flow channel has been simply modified so as to conduct in situ SPR measurements under polarization of an Au sensor chip at constant potentials. The modified instrument can monitor electrochemical reactions of monolayer materials with high stability and high reproducibility. The redox reaction of a self-assembled mon...

A microfluidic device with integrated surface plasmon resonance (SPR) chemical and biological sensors based on arrays of nanoholes in gold films is demonstrated. Widespread use of SPR for surface analysis in laboratories has not translated to microfluidic analytical chip platforms, in part due to challenges associated with scaling down the optics and the surface area required for common reflect...

Bloch surface waves (BSW) propagating at the boundary of truncated photonic crystals (1D-PC) have emerged as an attractive approach for label-free sensing in plasmon-like sensor configurations. Due to the very low losses in such dielectric thin film stacks, BSW feature very low angular resonance widths compared to the surface plasmon resonance (SPR) case. Besides label-free operation, the large...

This paper describes how the technique of surface plasmon resonance (SPR) can be utilized to follow (in real time) the attachment of Pseudomonas aeruginosa bacteria on bare gold and gold modified with a self-assembled monolayer (SAM) of mercaptounadecanoic acid. We show that SPR is able to discriminate between the adsorption of live versus dead (thermally shocked) bacteria. Moreover, the SPR di...

By combining a polymer-clad optic fiber and a vitreous-clad optic fiber, we proposed and fabricated a novel optic fiber surface plasmon resonance (SPR) sensor to conduct two-channel sensing at the same detection area. The traditional optic fiber SPR sensor has many disadvantages; for example, removing the cladding requires corrosion, operating it is dangerous, adjusting the dynamic response ran...

We validated the application of the surface plasmon resonance (SPR) technique to reliably determine adhesion of drugs to the intestinal wall using heparin-DOCA conjugates, developed to enhance the oral absorption of poorly absorbed heparin. In this study, heparin conjugates, or deoxycholyl-heparin (H-DOCA) and bisdeoxycholyl-heparin (H-bis-DOCA), were synthesized by covalently coupling the synt...