A popliteal nerve block may be used to provide anesthesia and extended analgesia of the lower extremity, to ameliorate severe and long lasting postoperative pain. The aim of this study was to elucidate the anatomical location of tibial (TN) and common peroneal (CPN) nerves in the popliteal crease for effective nerve block. Fifty fresh specimens from 27 adult Chinese cadavers (16 males and 11 fe...

Introduction: The heel has two parts, weight bearing and non-weight bearing part. Soft tissue heel reconstruction has been a challenge due to its complex nature of anatomy, weight bearing part of foot and the mechanism of injury requiring reconstruction. The pattern of injury includes from simple laceration to a complex wound with loss of soft tissue and fracture involving various degrees of ca...

Two patients with congenital hypomyelinating neuropathy are reported with details of sural nerve pathology. The resemblance of this condition to the hypomyelinating neuropathy of Trembler mice is discussed and the pertinent medical literature reviewed.

Some of the persons involved in an outbreak of ''yusho'' (polychlorinated biphenyl poisoning due to contaminated cooking oil) in Japan during the summer of 1968 complained of numbness or neuralgic limbs. Therefore, peripheral sensory nerve conduction velocity was measured in 21 such patients, and motor nerve conduction velocity in 19 of these. The motor nerve conduction velocity in the ulnar ne...

OBJECTIVES We aimed to determine whether ranirestat, an aldose reductase inhibitor, maintains the improved nerve function observed in patients with diabetic sensorimotor polyneuropathy (DSP) after completing a 12-week nerve biopsy study. RESEARCH DESIGN AND METHODS Patients with mild to moderate DSP, as determined by the presence of sural nerve responses, were enrolled in a double-blind, plac...

We examined the therapeutic effects of C-peptide on established nociceptive neuropathy in type 1 diabetic BB/Wor rats. Nociceptive nerve function, unmyelinated sural nerve fiber and dorsal root ganglion (DRG) cell morphometry, nociceptive peptide content, and the expression of neurotrophic factors and their receptors were investigated. C-peptide was administered either as a continuous subcutane...

Peripheral nerve injury alters the expression of hundreds of proteins in dorsal root ganglia (DRG). Targeting some of these proteins has led to successful treatments for acute pain, but not for sustained post-operative neuropathic pain. The latter may require targeting multiple proteins. Since a single microRNA (miR) can affect the expression of multiple proteins, here, we describe an approach ...