Wingless-type (Wnt) signaling through the secretion of Wnt inhibitors Dickkopf1, soluble frizzled-related protein-2 and -3 has a key role in the decreased osteoblast (OB) activity associated with multiple myeloma (MM) bone disease. We provide evidence that another Wnt antagonist, sclerostin, an osteocyte-expressed negative regulator of bone formation, is expressed by myeloma cells, that is, hum...

An input (e.g., airplane takeoff sound) to a sensory modality can suppress the percept of another input (e.g., talking voices of neighbors) of the same modality. This perceptual suppression effect is evidence that neural responses to different inputs closely interact with each other in the brain. While recent studies suggest that close interactions also occur across sensory modalities, crossmod...

We present a method for numerically generating a one-dimensional random surface, defined by the equation x(3)=zeta(x(1)), that suppresses single-scattering processes in the scattering of light from the surface within a specified range of scattering angles. Rigorous numerical calculations of the scattering of light from surfaces generated by this approach show that the single-scattering contribu...

See related article, pages 3511–3517. Wardlaw and colleagues1 use modeling to validate noninvasive imaging instead of intra-arterial angiography (IAA) for carotid stenosis. They conclude that duplex ultrasound (DUS) is best. There are not sufficient data with CT angiography (CTA) and MR angiography. Yet carotid CTA gives excellent anatomic depiction, has no stroke risk, and takes a few seconds ...

The growth of supermassive black holes and their host galaxies are thought to be linked, but the precise nature of this symbiotic relationship is still poorly understood. Both observations and simulations of galaxy formation suggest that the energy input from active galactic nuclei (AGN), as the central supermassive black hole accretes material and grows, heats the interstellar material and sup...

The pathogenesis of glucocorticoid-induced (GC-induced) bone loss is unclear. For example, osteoblast apoptosis is enhanced by GCs in vivo, but they stimulate bone formation in vitro. This conundrum suggests that an intermediary cell transmits a component of the bone-suppressive effects of GCs to osteoblasts in the intact animal. Bone remodeling is characterized by tethering of the activities o...

Th2-eosinophil immune responses are well known for mediating host defence against helminths. Herein we describe a function of Th2-eosinophil responses in counteracting the development of arthritis. In two independent models of arthritis, Nippostrongylus brasiliensis infection leads to Th2 and eosinophil accumulation in the joints associated with robust inhibition of arthritis and protection fro...

Dirac’s somewhat unfortunate statement about ‘interference between two (or more) photons never occurring‘ has led to fruitful discussions clarifying the understanding of interference from a quantum mechanical point of view. These days textbook presentations elucidate that single photon light fields behave just like classical states of light [1] when used in a Young’s double-slit interference ex...

A widespread myth asserts that all small universe models suppress the CMB quadrupole. In actual fact, some models suppress the quadrupole while others elevate it, according to whether their low-order modes are weak or strong relative to their high-order modes. Elementary geometrical reasoning shows that a model’s largest dimension determines the rough value lmin at which the CMB power spectrum ...