Gelatin-based films with an immobilized enzyme designed for extending the stability of the protein in dry, non-powder configuration with precise dosing attributes were subjected to stress conditions of temperature and relative humidity. β-galactosidase was used as model functional protein. The film configuration preserved the activity of the enzyme under the different storage conditions investi...

Article history: Received on: 12/10/2012 Revised on: 27/10/2012 Accepted on: 03/11/2012 Available online: 29/11/2012 Mini matrices containing Losartan potassium as a model drug were prepared by extrusion method using Hydroxy propyl methyl cellulose as matrix materials with or without xanthan gum and carbopol, and combination of xanthan gum and carbopol and propylene glycol as plasticizer. The p...

Diclofenac sodium as ophthalmic dosage form is used for the treatment of the pain, swelling and redness of patients' eyes recovering from cataract surgery; however, it faces the bioavailability limitation of eye drops due to effective protective mechanisms and corneal barrier functions in the eyes. Therefore, this investigation was aimed to develop ocular film formulations to achieve controlled...

Single-ion lithium conducting polymer electrolytes based on delocalized borate groups are designed and synthesized by rapid UV-photopolymerization. For this purpose, three different functional boron sp3 anionic monomers, containing fluorinated, ethoxy, or a blend of both functionalities synthesized. These monomers photopolymerized in the presence poly(ethylene glycol) dimethacrylate crosslinker...

Concrete is probably the most extensively used construction material in the world. The addition of mineral admixture in cement has dramatically increased along with the development of concrete industry, due to the consideration of cost saving, energy saving, environmental protection and conservation of resources. However, environmental concerns both in terms of damage caused by the extraction o...

the arithmetic mean roughness, ra, values were determined by scanning electron microscopic technique of different core models (furazolidone, nitrofurantoin and acetyl salicylic acid), coated by hpmc film forming solution containing 10 wt% of various molecular weight pegs. the results showed that both plasticizer molecular weight and core surface free energy could have a significant influence on...

The aim of this study was to develop novel transdermal films of ondansetron HCl with high molecular weight chitosan as matrix polymer and 2-(2-ethoxy-ethoxy) ethanol (Transcutol®) as plasticizer. In this context, firstly the physicochemical properties of gels used to formulate transdermal films were characterized and, physicochemical properties and bioadhesiveness of the transdermal films prepa...

The ability of di(2-ethylhexyl) phthalate (DEHP), a widely used plasticizer and environmental contaminant, to suppress development of putative preneoplastic lesions in rat liver was evaluated. gamma-Glutamyl transpeptidase-positive (GGT+) foci were initiated in the livers of Sprague-Dawley male rats with a single dose of diethylnitrosamine (DEN) following partial hepatectomy. Promotion of foci ...