Superoxide dismutases (SODs) are antioxidant enzymes that catalyze the dismutation of superoxide into hydrogen peroxide. There are 3 kinds of isozymes: extracellular superoxide dismutase (EC-SOD), manganese-containing superoxide dismutase (Mn-SOD) and copper- and zinc-containing superoxide dismutase (CuZn-SOD). To examine the expression of SOD isozymes in lungs injured by crystalline silica, we...

In recent years there is an upsurge in the areas related to newer developments in prevention of disease especially the role of free radicals and antioxidants. So it will be pertinent to examine the possible role of ‘free radicals’ in disease and ‘antioxidants’ in its prevention, especially the current status of the subject matter and future prospects. Numerous short-lived and highly reactive ox...

Depression and anxiety disorders are the most common mental health problems associated with oxidative stress. Although famous for its anxiolytic effect, antidepressant effect of valerian-hops combination was not previously studied, also relationship between sedative stress markers is unclear. The current research has two objectives: (1) to compare escitalopram (2) evaluate sedative/anxiolytic e...

Recent studies demonstrated that the proanthocyanidins (PA), the polymers of flavan-3-ols, naturally occurring plant metabolites widely available in fruits, vegetables, nuts, seeds, flowers and bark, have anti-inflammatory, anticarcinogenic, anti-allergic, antioxidant and vasodilatory actions. We hypothesized that Viburnum opulus PA (VOPA, Caprifoliaceae), due to activation of multifactorial ga...

The present study was undertaken in patients of ovarian malignancy to evaluate the status of oxidative stress and antioxidant defence mechanisms undergoing chemotherapy treatment. Circulating plasma lipid peroxides as malondialdehyde [MDA] and activities of the defensive enzymes (Superoxide Dismutase [SOD] and Catalase [CAT]) were measured. Blood samples were collected before treatment and with...

Melatonin plays several important physiological functions in mammals, such as immune enhancement and regulation of dark-light signal transduction. Melatonin is also known to be an endogenous free radical scavenger and an efficient antioxidant. It detoxifies a variety of free radicals and reactive oxygen intermediates, including the hydroxyl radical, singlet oxygen and nitric oxide. These radica...

Background: A significant number of diabetic patients develops diabetic nephropathy and correspondingly bring them at high risk for endstage renal disease and other long-term complications. Antioxidant enzymes may protect against the rapid onset and the progression of diabetic nephropathy. Mutations and polymorphisms in genes encoding such enzymes may, therefore, result in the predisposition to...

to estimate plant resistance to cadmium chloride (cdcl2) stress for phytoremediation purposes, the effect of cadmium (cd) phytotoxicity was assessed on total soluble protein, chlorophyll (chl) content and antioxidant enzymes in the leaves of three different brassica napus (b. napus) cultivars; mohican, reg.cob and okapi. plants were exposed to three levels of cdcl2 (0.75, 1.5 and 2.25 mm) in ir...