The asymmetric unit of the title compound, 2C18H12O4·C2H6OS·2H2O, consists of four crystallographically independent mol-ecules of 5-(naphthalen-1-yl)isophthalic acid, two dimethyl sulfoxide and four water mol-ecules. The dihedral angles formed by the the planes of the aromatic fragments of the organic mol-ecules range from 57.4 (1) to 59.1 (1)°. In the crystal, multiple O-H⋯O hydrogen bonds lin...

The asymmetric unit of the title compound, C(12)H(10)N(4)O(2)S(4)·2C(2)H(6)OS, contains one half of the p-xylene mol-ecule and one dimethyl sulfoxide mol-ecule. The p-xylene mol-ecule is located about a crystallographic inversion centre. In the mol-ecule, the thia-diazole and benzene rings are almost perpendicular to one another, with a dihedral angle of 88.95 (6)°. In the crystal, an N-H⋯O hyd...

The RNA synthesis of human leukemic leukocytes and phytohemagglutinin-stimulated lymphocytes is markedly reduced by administration of a low-molecular-weight nonhistone peptide factor from calf thymus. Treatment with the factor strongly inhibits hemoglobin production and globin mRNA transcription in dimethyl sulfoxide-stimulated Friend cells without appreciably modifying the rate of cell growth....

Msrs (methionine sulfoxide reductases), MsrA and MsrB, are repair enzymes that reduce methionine sulfoxide residues in oxidatively damaged proteins to methionine residues in a stereospecific manner. These enzymes protect cells from oxidative stress and have been implicated in delaying the aging process and progression of neurodegenerative diseases. In recent years, significant efforts have been...

Methionine sulfoxide has been shown to be a specific antagonist of glutamic acid in the conversion of glutamic acid to glutamine by Waelsch, Owades, Miller, and Borek (J. Biol. Chem., 166, 273, 1946) in growth inhibition studies with Lactobacillus arabinosus. Elliot and Gale (Nature, 161, 129, 1948) using cell-free extracts of Staphylococcus aureus have demonstrated that methionine sulfoxide in...

The 25-35 fragment of the amyloid β (Aβ) peptide is a naturally occurring proteolytic by-product of its larger parent molecule that retains the amyloid characteristics and toxicity of the full length parent molecule. Aggregation of this peptide occurs rapidly in aqueous solutions and thus characterization of its folding process is very difficult. In the present study, early stages of Aβ(25–35) ...